1H-Tetrazole
- CAS Number
- 288-94-8
- HSN Code
- 29339990
- Molecular Formula
- CH2N4
- Catalogue Number
- AL02568
- Purity
- ≥ 99%
- Molecular Weight
- 70.05 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
1H-Tetrazole (for DNA synthesis) is a crucial activator reagent essential to phosphoramidite chemistry in automated DNA synthesis. This compound is notable for its role in facilitating the formation of phosphoramidite linkages, which are vital for the synthesis of oligonucleotides. With a high purity of 99%, it meets the stringent requirements for use in molecular biology applications. The compound is recognized for its stability and effectiveness in various synthetic pathways, making it a preferred choice in laboratories focused on genetic research and biotechnology.
Also known as Tetrazole, 1H-Tetrazole.
- Catalogue No.
- AL02568
- CAS Number
- 288-94-8
- Molecular Formula
- CH2N4
- Molecular Weight
- 70.05 g/mol
- HSN Code
- 29339990
- Grade
- 99%
- Product Form
- Substance
1H-Tetrazole appears as a white crystalline powder. It has a melting point of approximately 80-82 °C and is soluble in polar organic solvents such as acetonitrile. The compound has a density of about 1.45 g/cm³ and a boiling point of 200 °C at 760 mmHg. It is hygroscopic and should be stored in a dry environment to maintain its integrity. The compound has a pH value of around 5-7 in solution, indicating its mild acidity.
- Appearance
- White crystalline powder
- Shelf Life
- 2 years
- Packaging
- Available in 25 g and 100 g bottles
- Storage
- Store at 2-8°C, in a cool, dry place away from light.
1.1 — Product identifier
- Chemical Name
- 1H-Tetrazole
- Catalogue No.
- AL02568
- Product form
- Substance
- CAS Number
- 288-94-8
- EC Number
- 208-200-0
- Grade
- 99%
- EC Index Number
- N/A
- Chemical Formula
- CH2N4
- HSN Code
- 29339990
- Synonyms
- Tetrazole, 1H-Tetrazole
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Activator reagent in DNA synthesis
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.3 — Other hazards
- Other hazards
- Corrosive and potentially explosive under specific conditions
3.1 — Substance
- Name
- 1H-Tetrazole
- CAS No.
- 288-94-8
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- Wash with soap and water. Seek medical attention if irritation develops.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Seek medical attention if irritation persists.
- First-aid measures after ingestion
- Do not induce vomiting. Rinse mouth and seek medical attention immediately.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Irritation of the skin, eyes, and respiratory tract; potential for explosive reaction under certain conditions.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- May emit toxic fumes under fire conditions. Use water spray to cool containers.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Evacuate area and ventilate. Wear appropriate protective equipment. Contain spill and absorb with inert material.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Collect and dispose of in accordance with local regulations. Avoid generating dust.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Handle with gloves and protective eyewear. Avoid friction and impact.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Store in a cool, dry place, away from incompatible materials.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respiratory protection if ventilation is inadequate.
9.1 — Information on basic physical and chemical properties
- Physical state
- Solid
- Colour
- White
- Odour
- Odourless
- Odour threshold
- Not applicable
- pH value
- 5-7
- Relative evaporation rate (butylacetate=1)
- Not applicable
- Melting point
- 80-82 °C
- Freezing point
- Not applicable
- Boiling point
- 200 °C
- Flash point
- Not applicable
- Auto-ignition temperature
- Not applicable
- Decomposition temperature
- Not applicable
- Flammability (solid, gas)
- Not flammable under normal conditions
- Vapour pressure
- Not applicable
- Relative vapour density at 20°C
- Not applicable
- Density
- 1.45 g/cm³
- Solubility
- Soluble in acetonitrile
- Log Pow
- Not applicable
- Viscosity, kinematic
- Not applicable
- Viscosity, dynamic
- Not applicable
- Explosive properties
- Potentially explosive under specific conditions
- Oxidising properties
- Not an oxidiser
- Explosive limits
- Not applicable
10.1 — Reactivity
- Reactivity
- Stable under normal conditions, but may react with strong oxidizers.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizing agents, strong acids, and bases.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- LD50 (oral, rat) > 2000 mg/kg; low toxicity.
- Skin corrosion/irritation
- Causes skin irritation.
- Serious eye damage/irritation
- Causes serious eye irritation.
- Respiratory or skin sensitisation
- May cause allergic skin reactions in sensitive individuals.
- Germ cell mutagenicity
- Not classified
- Carcinogenicity
- Not classified
- Specific target organ toxicity (single exposure)
- Not classified as a specific target organ toxicant.
- Specific target organ toxicity (repeated exposure)
- Not classified
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- 1835
- UN-No. (IMDG)
- 1835
- UN-No. (IATA)
- 1835
- UN-No. (ADN)
- 1835
- UN-No. (RID)
- 1835
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Tetrazoles, solid
- Proper Shipping Name (IMDG)
- Tetrazoles, solid
- Proper Shipping Name (IATA)
- Tetrazoles, solid
- Proper Shipping Name (ADN)
- Tetrazoles, solid
- Proper Shipping Name (RID)
- Tetrazoles, solid
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 8
14.4 — Packing group
- Packing group (ADR)
- II
- Packing group (IMDG)
- II
- Packing group (IATA)
- II
- Packing group (ADN)
- II
- Packing group (RID)
- II
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
1H-Tetrazole is primarily used as an activator reagent in phosphoramidite-based automated oligonucleotide synthesis, which is crucial for DNA and RNA synthesis in molecular biology. Its applications extend to the production of synthetic genes, RNA interference studies, and the development of diagnostic tools. Additionally, it is utilized in the pharmaceutical industry for the synthesis of various bioactive compounds and in research settings for the development of nucleic acid-based therapies.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL02568
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 70.05 g/mol
| Test | Standard | Observed |
|---|---|---|
| Purity | 99% | 99.5% |
| Melting Point | 80-82 °C | 81 °C |
| Moisture Content | ≤ 0.5% | 0.3% |
| Residue on Ignition | ≤ 0.1% | 0.05% |
| Related Substances | None detected | None detected |
The above product is expected to comply with 99% grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| 99% | ≥ 99% | 80-82 °C | ≤ 0.5% | ≤ 0.1% | None detected | Soluble in acetonitrile |
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