Tetrahydrofuran
- CAS Number
- 109-99-9
- HSN Code
- 29321100
- Molecular Formula
- C4H8O
- Catalogue Number
- AL1499A
- Purity
- 99.5%
- Molecular Weight
- 72.11 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Tetrahydrofuran (THF) is a colorless, water-miscible organic liquid with a distinctive ether-like odor. It is classified as a cyclic ether and is notable for its ability to dissolve a wide range of polar and nonpolar compounds, making it a versatile solvent in various chemical processes. This AR-grade tetrahydrofuran has a purity of 99.5%, which is significantly higher than that of technical or synthesis grades, ensuring minimal impurities for sensitive applications. The product is stabilized with 0.1% quinol to prevent the formation of peroxides, which can occur upon exposure to air and light.
Also known as THF, 1,4-Butyrolactone.
- Catalogue No.
- AL1499A
- CAS Number
- 109-99-9
- Molecular Formula
- C4H8O
- Molecular Weight
- 72.11 g/mol
- HSN Code
- 29321100
- Grade
- AR grade
- Product Form
- Substance
Tetrahydrofuran is a colorless liquid with a density of 0.889 g/mL at 20°C. It has a boiling point of approximately 66°C and a melting point of -108°C. The liquid has a flash point of -14°C, indicating its high flammability. THF is miscible with water, ethanol, and ether, and has a vapor pressure of about 160 mmHg at 20°C. Its refractive index is around 1.407, and it has a low viscosity of approximately 0.36 mPa·s at 20°C.
- Appearance
- Colorless liquid
- Shelf Life
- 12 months
- Packaging
- Available in 1L, 5L, and 25L containers
- Storage
- Store in a cool, well-ventilated area away from sources of ignition and incompatible materials.
1.1 — Product identifier
- Chemical Name
- Tetrahydrofuran
- Catalogue No.
- AL1499A
- Product form
- Substance
- CAS Number
- 109-99-9
- EC Number
- 203-726-8
- Grade
- AR grade
- EC Index Number
- 607-195-00-7
- Chemical Formula
- C4H8O
- HSN Code
- 29321100
- Synonyms
- THF, 1,4-Butyrolactone
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Solvent in chemical synthesis and analytical applications
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.3 — Other hazards
- Other hazards
- Forms explosive peroxides upon exposure to air and light.
3.1 — Substance
- Name
- Tetrahydrofuran
- CAS No.
- 109-99-9
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If breathing is difficult, give oxygen. Seek medical attention if symptoms persist.
- First-aid measures after skin contact
- Wash with soap and water. Remove contaminated clothing. Seek medical attention if irritation develops.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Seek medical attention if irritation persists.
- First-aid measures after ingestion
- Do not induce vomiting. Rinse mouth and seek medical attention immediately.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Headache, dizziness, nausea, respiratory irritation, skin and eye irritation.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- Highly flammable. Vapors may form explosive mixtures with air.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Evacuate area. Remove all sources of ignition. Ventilate area.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Contain spill with inert material and transfer to a suitable container for disposal. Avoid runoff into waterways.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Use in a well-ventilated area. Avoid contact with skin and eyes. Keep away from heat and open flames.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Store in tightly closed containers in a cool, dry, well-ventilated area away from incompatible materials.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respiratory protection if ventilation is inadequate.
9.1 — Information on basic physical and chemical properties
- Physical state
- Liquid
- Colour
- Colorless
- Odour
- Ether-like
- Odour threshold
- Not specified
- pH value
- Not applicable
- Relative evaporation rate (butylacetate=1)
- Not specified
- Melting point
- -108°C
- Freezing point
- Not specified
- Boiling point
- 66°C
- Flash point
- -14°C
- Auto-ignition temperature
- Not specified
- Decomposition temperature
- Not specified
- Flammability (solid, gas)
- Highly flammable
- Vapour pressure
- 160 mmHg at 20°C
- Relative vapour density at 20°C
- Not specified
- Density
- 0.889 g/mL
- Solubility
- Miscible with water, ethanol, and ether
- Log Pow
- Not specified
- Viscosity, kinematic
- Not specified
- Viscosity, dynamic
- 0.36 mPa·s at 20°C
- Explosive properties
- Forms explosive peroxides
- Oxidising properties
- Not specified
- Explosive limits
- Not specified
10.1 — Reactivity
- Reactivity
- Reacts violently with strong oxidizers and can form peroxides upon exposure to air.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizing agents, strong acids, and bases.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- Oral LD50 (rat): 1,500 mg/kg; Dermal LD50 (rabbit): 1,000 mg/kg.
- Skin corrosion/irritation
- Causes skin irritation.
- Serious eye damage/irritation
- Causes serious eye irritation.
- Respiratory or skin sensitisation
- Not a skin sensitizer.
- Germ cell mutagenicity
- Not classified
- Carcinogenicity
- Not classified
- Specific target organ toxicity (single exposure)
- May cause respiratory irritation.
- Specific target organ toxicity (repeated exposure)
- Not classified
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- 2056
- UN-No. (IMDG)
- 2056
- UN-No. (IATA)
- 2056
- UN-No. (ADN)
- 2056
- UN-No. (RID)
- 2056
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Tetrahydrofuran
- Proper Shipping Name (IMDG)
- Tetrahydrofuran
- Proper Shipping Name (IATA)
- Tetrahydrofuran
- Proper Shipping Name (ADN)
- Tetrahydrofuran
- Proper Shipping Name (RID)
- Tetrahydrofuran
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 3
14.4 — Packing group
- Packing group (ADR)
- II
- Packing group (IMDG)
- II
- Packing group (IATA)
- II
- Packing group (ADN)
- II
- Packing group (RID)
- II
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Tetrahydrofuran is widely used as a solvent in the production of polymers, particularly in the manufacture of poly tetrahydrofuran (PTMEG), which is used in elastomers and spandex fibers. It is also employed in the pharmaceutical industry for the synthesis of various compounds and as a reaction medium in Grignard reactions. Additionally, THF serves as a solvent for coatings, adhesives, and in the extraction of natural products. Its high purity makes it suitable for analytical applications, including chromatography and spectroscopy.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL1499A
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 72.11 g/mol
| Test | Standard | Observed |
|---|---|---|
| Purity | 99.5% min | 99.7% |
| Moisture Content | <0.1% | 0.05% |
| Residue on Ignition | <0.01% | 0.005% |
| Related Substances | <0.5% | 0.3% |
| Solubility | Miscible with water | Miscible |
The above product is expected to comply with AR grade grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| AR | 99.5% | -108°C / 66°C | <0.1% | <0.01% | <0.5% | Miscible with water |
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