Thiobarbituric Acid
- CAS Number
- 504-17-6
- HSN Code
- 29335200
- Molecular Formula
- C4H4N2O2S
- Catalogue Number
- AL1501A
- Purity
- ≥ 98%
- Molecular Weight
- 144.15 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Thiobarbituric acid (AR) is a well-known reagent essential to the TBARS assay for measuring lipid peroxidation. It is a derivative of barbituric acid, characterized by the presence of a thiol group, which enhances its reactivity and utility in biochemical assays. This compound is widely used in laboratories for its ability to form colored complexes with malondialdehyde, a byproduct of lipid peroxidation, making it a crucial tool in studies related to oxidative stress and cellular damage. Thiobarbituric acid is recognized for its high purity and reliability in analytical applications, particularly in the fields of biochemistry and molecular biology.
Also known as 2-Thiobarbituric acid.
- Catalogue No.
- AL1501A
- CAS Number
- 504-17-6
- Molecular Formula
- C4H4N2O2S
- Molecular Weight
- 144.15 g/mol
- HSN Code
- 29335200
- Grade
- AR (Analytical Reagent)
- Product Form
- Substance
Thiobarbituric acid appears as a white to pale yellow crystalline powder. It has a melting point of approximately 200 °C and is soluble in water, allowing for easy preparation of solutions for laboratory use. The compound has a density of about 1.4 g/cm³ and exhibits a slight odor. Its solubility in water is significant, facilitating its use in various aqueous assays. The compound is stable under normal conditions but should be stored in a cool, dry place to maintain its integrity.
- Appearance
- White to pale yellow crystalline powder
- Shelf Life
- 2 years
- Packaging
- Available in 100 g and 500 g bottles
- Storage
- Store in a cool, dry place, away from light.
1.1 — Product identifier
- Chemical Name
- Thiobarbituric Acid
- Catalogue No.
- AL1501A
- Product form
- Substance
- CAS Number
- 504-17-6
- EC Number
- 207-202-0
- Grade
- AR
- EC Index Number
- Not applicable
- Chemical Formula
- C4H4N2O2S
- HSN Code
- 29335200
- Synonyms
- 2-Thiobarbituric acid
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Reagent for TBARS assay
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.3 — Other hazards
- Other hazards
- None identified
3.1 — Substance
- Name
- Thiobarbituric Acid
- CAS No.
- 504-17-6
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- Wash with soap and water. If irritation occurs, seek medical attention.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. If irritation persists, seek medical attention.
- First-aid measures after ingestion
- Rinse mouth. Do not induce vomiting. Seek medical attention if symptoms occur.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Mild irritation to skin, eyes, and respiratory tract.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- Non-flammable, but may emit toxic fumes in a fire.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Contain spill and collect using appropriate protective equipment. Dispose of in accordance with local regulations.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Use appropriate personal protective equipment. Sweep up and place in a suitable container for disposal.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Avoid contact with skin and eyes. Use gloves and safety goggles when handling.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Store in a cool, dry place, away from incompatible materials.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Not required under normal conditions; use in a well-ventilated area.
9.1 — Information on basic physical and chemical properties
- Physical state
- Solid
- Colour
- White to pale yellow
- Odour
- Slight
- Odour threshold
- Not applicable
- pH value
- Not applicable
- Relative evaporation rate (butylacetate=1)
- Not applicable
- Melting point
- 200 °C
- Freezing point
- Not applicable
- Boiling point
- Not applicable
- Flash point
- Not applicable
- Auto-ignition temperature
- Not applicable
- Decomposition temperature
- Not applicable
- Flammability (solid, gas)
- Not flammable
- Vapour pressure
- Not applicable
- Relative vapour density at 20°C
- Not applicable
- Density
- 1.4 g/cm³
- Solubility
- Soluble in water
- Log Pow
- Not applicable
- Viscosity, kinematic
- Not applicable
- Viscosity, dynamic
- Not applicable
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- Not applicable
10.1 — Reactivity
- Reactivity
- Stable under normal conditions; avoid strong oxidizing agents.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizing agents.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- Low toxicity; LD50 (oral, rat) > 2000 mg/kg.
- Skin corrosion/irritation
- Mild irritant.
- Serious eye damage/irritation
- Mild irritant.
- Respiratory or skin sensitisation
- Not sensitizing.
- Germ cell mutagenicity
- Not classified
- Carcinogenicity
- Not classified
- Specific target organ toxicity (single exposure)
- Not classified as a specific target organ toxicant.
- Specific target organ toxicity (repeated exposure)
- Not classified
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- UN 3335
- UN-No. (IMDG)
- UN 3335
- UN-No. (IATA)
- UN 3335
- UN-No. (ADN)
- UN 3335
- UN-No. (RID)
- UN 3335
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Environmentally hazardous substance, solid, n.o.s.
- Proper Shipping Name (IMDG)
- Environmentally hazardous substance, solid, n.o.s.
- Proper Shipping Name (IATA)
- Environmentally hazardous substance, solid, n.o.s.
- Proper Shipping Name (ADN)
- Environmentally hazardous substance, solid, n.o.s.
- Proper Shipping Name (RID)
- Environmentally hazardous substance, solid, n.o.s.
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 9
14.4 — Packing group
- Packing group (ADR)
- III
- Packing group (IMDG)
- III
- Packing group (IATA)
- III
- Packing group (ADN)
- III
- Packing group (RID)
- III
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Thiobarbituric acid is primarily used as a key reagent in the TBARS (thiobarbituric acid reactive substances) assay, which is a widely accepted method for measuring lipid peroxidation and oxidative stress in biological samples. This assay is crucial in research related to aging, cancer, cardiovascular diseases, and neurodegenerative disorders. Additionally, thiobarbituric acid is utilized in food science to assess the oxidative stability of lipids in food products, helping to evaluate shelf life and quality. Its applications extend to pharmacology and toxicology, where it aids in understanding the effects of various substances on lipid metabolism.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL1501A
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 144.15 g/mol
| Test | Standard | Observed |
|---|---|---|
| Description | White/Cream colored crystalline powder | White/Cream colored crystalline powder |
| Assay | (Min.) 99.0% | 99.74% |
| pH (1% water) | 1.7 to 1.9 | 1.87 |
| Loss on drying | <1% | 0.74% |
| Suitability as reagent for sorbic acid | Passes test | Passes test |
| IR spectrum | Passes test | Passes test |
| TLC test | Passes test | Passes test |
The above product complies with AR grade
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| 98% AR | ≥ 98% | 200 °C | ≤ 1% | ≤ 0.5% | None detected | Soluble in water |
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