Methanesulfonyl chloride
- CAS Number
- 124-63-0
- HSN Code
- 29049990
- Molecular Formula
- CH3ClO2S
- Catalogue Number
- AL1000A
- Purity
- ≥ 99%
- Molecular Weight
- 114.55 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Methanesulfonyl chloride (mesyl chloride) is a highly reactive sulfonylating reagent widely used to activate alcohols as leaving groups (mesylates). It is essential in organic synthesis for the preparation of various derivatives.
Also known as Mesyl chloride.
- Catalogue No.
- AL1000A
- CAS Number
- 124-63-0
- Molecular Formula
- CH3ClO2S
- Molecular Weight
- 114.55 g/mol
- HSN Code
- 29049990
- Grade
- 99% For Synthesis
- Product Form
- Substance
Colorless to pale yellow liquid with a density of 1.48 g/mL and a pungent odor. It has a boiling point of 80-82 °C and a flash point of 25 °C.
- Appearance
- Colorless to pale yellow liquid
- Shelf Life
- 12 months
- Packaging
- Available in 100 mL and 500 mL glass bottles
- Storage
- Store in a cool, dry place away from moisture and incompatible materials.
1.1 — Product identifier
- Chemical Name
- Methanesulfonyl chloride
- Catalogue No.
- AL1000A
- Product form
- Substance
- CAS Number
- 124-63-0
- EC Number
- 204-711-0
- Grade
- 99% For Synthesis
- EC Index Number
- 650-002-00-6
- Chemical Formula
- CH3ClO2S
- HSN Code
- 29049990
- Synonyms
- Mesyl chloride
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Reagent for organic synthesis
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.3 — Other hazards
- Other hazards
- Corrosive to metals; may cause severe skin burns and eye damage.
3.1 — Substance
- Name
- Methanesulfonyl chloride
- CAS No.
- 124-63-0
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Remove to fresh air. If breathing is difficult, give oxygen. Seek medical attention immediately.
- First-aid measures after skin contact
- Remove contaminated clothing. Rinse skin with plenty of water for at least 15 minutes. Seek medical attention.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing and seek medical attention.
- First-aid measures after ingestion
- Do not induce vomiting. Rinse mouth and seek medical attention immediately.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Cough, shortness of breath, skin burns, eye irritation.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- May produce toxic fumes in a fire. Use water spray to cool containers.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Evacuate area. Wear appropriate protective equipment. Contain spill and absorb with inert material.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Neutralize with sodium bicarbonate or lime. Dispose of in accordance with local regulations.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Use in a fume hood with appropriate PPE including gloves and goggles. Avoid contact with skin and eyes.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Store in tightly closed containers in a cool, dry, well-ventilated area away from incompatible substances.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use a NIOSH-approved respirator if exposure limits are exceeded.
9.1 — Information on basic physical and chemical properties
- Physical state
- Liquid
- Colour
- Colorless to pale yellow
- Odour
- Pungent
- Odour threshold
- Not specified
- pH value
- Not applicable
- Relative evaporation rate (butylacetate=1)
- Not specified
- Melting point
- -50 °C
- Freezing point
- Not specified
- Boiling point
- 80-82 °C
- Flash point
- 25 °C
- Auto-ignition temperature
- Not specified
- Decomposition temperature
- Not specified
- Flammability (solid, gas)
- Not flammable
- Vapour pressure
- Not specified
- Relative vapour density at 20°C
- Not specified
- Density
- 1.48 g/mL
- Solubility
- Soluble in water, alcohols, and ethers
- Log Pow
- Not specified
- Viscosity, kinematic
- Not specified
- Viscosity, dynamic
- Not specified
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- Not specified
10.1 — Reactivity
- Reactivity
- Reacts violently with water, alcohols, and amines.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong bases, strong oxidizers, and water.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- Highly toxic; LD50 (oral, rat) 200 mg/kg.
- Skin corrosion/irritation
- Causes severe skin burns.
- Serious eye damage/irritation
- Causes serious eye damage.
- Respiratory or skin sensitisation
- May cause allergic skin reactions.
- Germ cell mutagenicity
- Not classified
- Carcinogenicity
- Not classified
- Specific target organ toxicity (single exposure)
- May cause respiratory irritation.
- Specific target organ toxicity (repeated exposure)
- Not classified
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- UN 3246
- UN-No. (IMDG)
- UN 3246
- UN-No. (IATA)
- UN 3246
- UN-No. (ADN)
- UN 3246
- UN-No. (RID)
- UN 3246
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Methanesulfonyl chloride
- Proper Shipping Name (IMDG)
- Methanesulfonyl chloride
- Proper Shipping Name (IATA)
- Methanesulfonyl chloride
- Proper Shipping Name (ADN)
- Methanesulfonyl chloride
- Proper Shipping Name (RID)
- Methanesulfonyl chloride
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 6.1 (8)
14.4 — Packing group
- Packing group (ADR)
- I
- Packing group (IMDG)
- I
- Packing group (IATA)
- I
- Packing group (ADN)
- I
- Packing group (RID)
- I
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Used to convert alcohols into mesylate leaving groups for subsequent substitution reactions in organic and pharmaceutical synthesis. It is also utilized in the synthesis of sulfonamides and other sulfonyl compounds.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL1000A
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 114.55 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay | ≥ 99% | 99.5% |
| Moisture Content | ≤ 0.5% | 0.3% |
| Residue on Ignition | ≤ 0.1% | 0.05% |
| Related Substances | None detected | None detected |
The above product is expected to comply with 99% For Synthesis grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| 99% For Synthesis | ≥ 99% | 80-82 °C | ≤ 0.5% | ≤ 0.1% | None detected | Soluble in water and organic solvents |
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