p-Toluenesulfonyl fluoride
- CAS Number
- 455-16-3
- HSN Code
- 29049990
- Molecular Formula
- C7H7O2S
- Catalogue Number
- AL1530D
- Purity
- ≥ 98%
- Molecular Weight
- 174.19 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
p-Toluenesulfonyl fluoride (tosyl fluoride) is a sulfonyl halide that serves as a versatile synthetic reagent and protease inhibitor. It is particularly notable for its role in biochemical applications, where it is utilized to inhibit serine proteases, making it valuable in various research settings. The compound is characterized by its high purity of 98%, ensuring its effectiveness in laboratory applications. With a molecular formula of CH3C6H4SO2F and a molecular weight of 174.19 g/mol, p-toluenesulfonyl fluoride is an essential reagent in organic synthesis and biochemistry.
Also known as tosyl fluoride.
- Catalogue No.
- AL1530D
- CAS Number
- 455-16-3
- Molecular Formula
- C7H7O2S
- Molecular Weight
- 174.19 g/mol
- HSN Code
- 29049990
- Grade
- 98%
- Product Form
- Substance
p-Toluenesulfonyl fluoride appears as a white to pale yellow crystalline solid or liquid, depending on its form. It has a melting point of approximately 20-22 °C and a boiling point of around 130 °C at 0.5 mmHg. The compound has a density of about 1.25 g/cm³ and is soluble in organic solvents such as acetone and dichloromethane, but it is not soluble in water. Its vapour pressure is relatively low, indicating stability under standard conditions.
- Appearance
- White to pale yellow crystalline solid or liquid
- Shelf Life
- Stable under recommended storage conditions
- Packaging
- Available in various packaging options, including glass bottles and plastic containers
- Storage
- Store in a cool, dry place away from incompatible materials, in tightly closed containers.
1.1 — Product identifier
- Chemical Name
- p-Toluenesulfonyl fluoride
- Catalogue No.
- AL1530D
- Product form
- Substance
- CAS Number
- 455-16-3
- EC Number
- 207-312-8
- Grade
- 98%
- EC Index Number
- 607-007-00-0
- Chemical Formula
- C7H7O2S
- HSN Code
- 29049990
- Synonyms
- tosyl fluoride
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Used as a protease inhibitor and synthetic reagent in biochemical research.
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.3 — Other hazards
- Other hazards
- Corrosive to metals; may cause skin and eye burns.
3.1 — Substance
- Name
- p-Toluenesulfonyl fluoride
- CAS No.
- 455-16-3
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- Wash skin thoroughly with soap and water. Remove contaminated clothing. Seek medical attention if irritation develops.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing and seek medical attention.
- First-aid measures after ingestion
- Do not induce vomiting. Rinse mouth and seek medical attention immediately.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- May cause irritation to the respiratory tract, skin, and eyes. Symptoms may include coughing, redness, and pain.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- May emit toxic fumes in a fire. Use appropriate fire-fighting measures.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Evacuate area and ventilate. Wear appropriate protective equipment. Contain and collect spill for disposal.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Absorb spill with inert material and place in a chemical waste container. Dispose of in accordance with local regulations.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Handle in a fume hood. Wear appropriate personal protective equipment, including gloves and goggles.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Store in a cool, dry place, away from incompatible materials such as strong bases and oxidizers.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respiratory protection if ventilation is inadequate.
9.1 — Information on basic physical and chemical properties
- Physical state
- Solid
- Colour
- White to pale yellow
- Odour
- Slightly aromatic
- Odour threshold
- No data available
- pH value
- No data available
- Relative evaporation rate (butylacetate=1)
- No data available
- Melting point
- 20-22 °C
- Freezing point
- No data available
- Boiling point
- 130 °C at 0.5 mmHg
- Flash point
- No data available
- Auto-ignition temperature
- No data available
- Decomposition temperature
- No data available
- Flammability (solid, gas)
- Not flammable under normal conditions
- Vapour pressure
- Low, approximately 0.1 mmHg at 25 °C
- Relative vapour density at 20°C
- No data available
- Density
- 1.25 g/cm³
- Solubility
- Soluble in organic solvents, insoluble in water
- Log Pow
- No data available
- Viscosity, kinematic
- No data available
- Viscosity, dynamic
- No data available
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- No data available
10.1 — Reactivity
- Reactivity
- Stable under normal conditions; reacts with strong bases and oxidizing agents.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong bases, strong oxidizers, and moisture.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- Toxic if inhaled or absorbed through skin; may cause burns.
- Skin corrosion/irritation
- Causes skin irritation; may cause burns.
- Serious eye damage/irritation
- Causes serious eye damage.
- Respiratory or skin sensitisation
- May cause allergic skin reactions in sensitive individuals.
- Germ cell mutagenicity
- Not classified
- Carcinogenicity
- Not classified
- Specific target organ toxicity (single exposure)
- May cause respiratory irritation.
- Specific target organ toxicity (repeated exposure)
- Not classified
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- UN 3261
- UN-No. (IMDG)
- UN 3261
- UN-No. (IATA)
- UN 3261
- UN-No. (ADN)
- UN 3261
- UN-No. (RID)
- UN 3261
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Corrosive solid, acidic, organic, n.o.s.
- Proper Shipping Name (IMDG)
- Corrosive solid, acidic, organic, n.o.s.
- Proper Shipping Name (IATA)
- Corrosive solid, acidic, organic, n.o.s.
- Proper Shipping Name (ADN)
- Corrosive solid, acidic, organic, n.o.s.
- Proper Shipping Name (RID)
- Corrosive solid, acidic, organic, n.o.s.
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 8
14.4 — Packing group
- Packing group (ADR)
- II
- Packing group (IMDG)
- II
- Packing group (IATA)
- II
- Packing group (ADN)
- II
- Packing group (RID)
- II
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
p-Toluenesulfonyl fluoride is widely used in biochemistry as a serine protease inhibitor, making it a critical tool in the study of enzyme mechanisms and protein interactions. It is also employed as a sulfonylating agent in organic synthesis, facilitating the introduction of sulfonyl groups into various substrates. Additionally, this compound finds applications in the pharmaceutical industry for the development of drugs targeting proteolytic enzymes. Its utility extends to the synthesis of sulfonamide compounds and other derivatives in chemical research.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL1530D
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 174.19 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay | ≥ 98% | 99.5% |
| Melting Point | 20-22 °C | 21 °C |
| Moisture Content | ≤ 0.5% | 0.3% |
| Residue on Ignition | ≤ 0.1% | 0.05% |
| Related Substances | None detected | None detected |
The above product is expected to comply with 98% grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| 98% | ≥ 98% | 20-22 °C | ≤ 0.5% | ≤ 0.1% | None detected | Soluble in organic solvents |
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