p-Toluoyl chloride
- CAS Number
- 874-60-2
- HSN Code
- 29163990
- Molecular Formula
- C8H7OCl
- Catalogue Number
- AL1535C
- Purity
- ≥ 98%
- Molecular Weight
- 154.59 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
p-Toluoyl chloride, also known as 4-toluoyl chloride, is a reactive acyl chloride that serves as an important acylating reagent in organic synthesis. It is characterized by its ability to introduce acyl groups into various organic compounds, making it a valuable intermediate in the synthesis of pharmaceuticals, agrochemicals, and fine chemicals. With a purity of 98%, this compound is suitable for high-precision applications in research and industrial settings. Its reactivity and specificity make it a preferred choice for chemists working in synthetic organic chemistry.
Also known as 4-Toluoyl chloride, p-Toluoyl chloride.
- Catalogue No.
- AL1535C
- CAS Number
- 874-60-2
- Molecular Formula
- C8H7OCl
- Molecular Weight
- 154.59 g/mol
- HSN Code
- 29163990
- Grade
- 98%
- Product Form
- Substance
p-Toluoyl chloride is a colorless to pale yellow liquid with a density of 1.17 g/mL. It has a pungent odor, characteristic of acyl chlorides, and is known to be moisture-reactive. The boiling point of p-toluoyl chloride is approximately 202 °C, and it has a melting point of -5 °C. It is soluble in organic solvents such as dichloromethane and ether but reacts with water, releasing hydrochloric acid. The compound has a flash point of 85 °C, indicating that it should be handled with care to avoid ignition sources.
- Appearance
- Colorless to pale yellow liquid
- Shelf Life
- 2 years
- Packaging
- Available in 500 mL glass bottles
- Storage
- Store in a cool, dry place away from moisture and incompatible materials.
1.1 — Product identifier
- Chemical Name
- p-Toluoyl chloride
- Catalogue No.
- AL1535C
- Product form
- Substance
- CAS Number
- 874-60-2
- EC Number
- 212-828-2
- Grade
- 98%
- EC Index Number
- 607-007-00-4
- Chemical Formula
- C8H7OCl
- HSN Code
- 29163990
- Synonyms
- 4-Toluoyl chloride, p-Toluoyl chloride
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Acylating reagent in organic synthesis
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.3 — Other hazards
- Other hazards
- Corrosive to metals; may cause skin burns and eye damage.
3.1 — Substance
- Name
- p-Toluoyl chloride
- CAS No.
- 874-60-2
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- Wash skin thoroughly with soap and water. Seek medical attention if irritation develops.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing and seek medical attention.
- First-aid measures after ingestion
- Do not induce vomiting. Rinse mouth and seek medical attention immediately.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Burning sensation, respiratory distress, skin irritation, and eye damage.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- May produce toxic fumes in a fire. Use water spray to cool containers.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Evacuate area and ventilate. Wear appropriate protective equipment. Contain and absorb spill with inert material.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Collect spillage and dispose of in accordance with local regulations.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Handle in a fume hood with appropriate personal protective equipment (PPE). Avoid contact with skin and eyes.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Store in tightly closed containers in a cool, dry place away from moisture and incompatible materials.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respiratory protection if ventilation is inadequate.
9.1 — Information on basic physical and chemical properties
- Physical state
- Liquid
- Colour
- Colorless to pale yellow
- Odour
- Pungent
- Odour threshold
- No data available
- pH value
- No data available
- Relative evaporation rate (butylacetate=1)
- No data available
- Melting point
- -5 °C
- Freezing point
- No data available
- Boiling point
- 202 °C
- Flash point
- 85 °C
- Auto-ignition temperature
- No data available
- Decomposition temperature
- No data available
- Flammability (solid, gas)
- Not applicable
- Vapour pressure
- No data available
- Relative vapour density at 20°C
- No data available
- Density
- 1.17 g/mL
- Solubility
- Soluble in organic solvents; reacts with water
- Log Pow
- No data available
- Viscosity, kinematic
- No data available
- Viscosity, dynamic
- No data available
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- No data available
10.1 — Reactivity
- Reactivity
- Reacts violently with water, releasing hydrochloric acid and forming p-toluic acid.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Water, strong bases, strong oxidizing agents.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- Toxic if inhaled or absorbed through skin; may cause burns.
- Skin corrosion/irritation
- Causes severe skin burns.
- Serious eye damage/irritation
- Causes serious eye damage.
- Respiratory or skin sensitisation
- May cause allergic skin reactions in sensitive individuals.
- Germ cell mutagenicity
- Not classified
- Carcinogenicity
- Not classified
- Specific target organ toxicity (single exposure)
- May cause respiratory irritation.
- Specific target organ toxicity (repeated exposure)
- Not classified
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- UN 3265
- UN-No. (IMDG)
- UN 3265
- UN-No. (IATA)
- UN 3265
- UN-No. (ADN)
- UN 3265
- UN-No. (RID)
- UN 3265
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Corrosive liquid, acidic, organic, n.o.s. (p-Toluoyl chloride)
- Proper Shipping Name (IMDG)
- Corrosive liquid, acidic, organic, n.o.s. (p-Toluoyl chloride)
- Proper Shipping Name (IATA)
- Corrosive liquid, acidic, organic, n.o.s. (p-Toluoyl chloride)
- Proper Shipping Name (ADN)
- Corrosive liquid, acidic, organic, n.o.s. (p-Toluoyl chloride)
- Proper Shipping Name (RID)
- Corrosive liquid, acidic, organic, n.o.s. (p-Toluoyl chloride)
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 8
14.4 — Packing group
- Packing group (ADR)
- II
- Packing group (IMDG)
- II
- Packing group (IATA)
- II
- Packing group (ADN)
- II
- Packing group (RID)
- II
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
p-Toluoyl chloride is widely used as an acylating agent in the synthesis of various organic compounds, particularly in the pharmaceutical and fine chemical industries. It is instrumental in the preparation of esters, amides, and other derivatives that are crucial in drug development and chemical research. Additionally, it finds applications in the production of agrochemicals and in the formulation of specialty chemicals. Its role in organic synthesis extends to the modification of natural products and the development of new materials, making it a versatile reagent in chemical laboratories.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL1535C
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 154.59 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay | ≥ 98% | 99.5% |
| Moisture Content | ≤ 0.5% | 0.2% |
| Residue on Ignition | ≤ 0.1% | 0.05% |
| Related Substances | None detected | None detected |
The above product is expected to comply with 98% grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| 98% | ≥ 98% | -5 °C / 202 °C | ≤ 0.5% | ≤ 0.1% | None detected | Soluble in organic solvents |
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