Procaine Hydrochloride
- CAS Number
- 51-05-8
- HSN Code
- 29224990
- Molecular Formula
- C13H20N2O2·HCl
- Catalogue Number
- AL02484
- Purity
- 97% min
- Molecular Weight
- 272.77 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Procaine hydrochloride (extra pure, neocaine) is a widely used local anesthetic drug, one of the original synthetic replacements for cocaine. It is primarily utilized in medical settings for its anesthetic properties, providing pain relief during surgical procedures. This compound is notable for its rapid onset and relatively short duration of action, making it suitable for various minor surgical interventions. Procaine hydrochloride is also employed in pharmaceutical research as a reference standard for quality control and formulation development.
Also known as Neocaine.
- Catalogue No.
- AL02484
- CAS Number
- 51-05-8
- Molecular Formula
- C13H20N2O2·HCl
- Molecular Weight
- 272.77 g/mol
- HSN Code
- 29224990
- Grade
- 97% Extra Pure
- Product Form
- Substance
Procaine hydrochloride appears as a white crystalline powder. It has a melting point of approximately 170-175 °C and is freely soluble in water, which facilitates its use in injectable formulations. The compound has a density of about 1.1 g/cm³ and a pH in solution typically ranging from 4.5 to 6.5. Its solubility in water is significant, allowing for effective delivery in medical applications. The compound has a slight characteristic odor, typical of local anesthetics.
- Appearance
- White crystalline powder
- Shelf Life
- 2 years
- Packaging
- Available in 100 g and 500 g containers
- Storage
- Store in a cool, dry place, away from light.
1.1 — Product identifier
- Chemical Name
- Procaine Hydrochloride
- Catalogue No.
- AL02484
- Product form
- Substance
- CAS Number
- 51-05-8
- EC Number
- 218-200-0
- Grade
- 97% Extra Pure
- EC Index Number
- Not applicable
- Chemical Formula
- C13H20N2O2·HCl
- HSN Code
- 29224990
- Synonyms
- Neocaine
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Local anesthetic, reference standard in pharmaceutical quality control
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.3 — Other hazards
- Other hazards
- Pharmacologically active compound; handle with care.
3.1 — Substance
- Name
- Procaine Hydrochloride
- CAS No.
- 51-05-8
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- Wash with soap and water. If irritation occurs, seek medical attention.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Seek medical attention if irritation persists.
- First-aid measures after ingestion
- Do not induce vomiting. Rinse mouth and seek medical attention immediately.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Symptoms of exposure may include dizziness, headache, and allergic reactions such as rash or itching.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- May emit toxic fumes in a fire. Use appropriate fire-fighting measures.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Contain spill and collect using appropriate protective equipment. Dispose of in accordance with local regulations.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Use appropriate personal protective equipment. Sweep up and place in a suitable container for disposal.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Handle with gloves and avoid contact with skin and eyes. Use in a well-ventilated area.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Store in a cool, dry place, away from incompatible materials.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respiratory protection if dust is generated.
9.1 — Information on basic physical and chemical properties
- Physical state
- Solid
- Colour
- White
- Odour
- Slight characteristic odor
- Odour threshold
- Not applicable
- pH value
- 4.5 - 6.5 (in solution)
- Relative evaporation rate (butylacetate=1)
- Not applicable
- Melting point
- 170-175 °C
- Freezing point
- Not applicable
- Boiling point
- Not applicable
- Flash point
- Not applicable
- Auto-ignition temperature
- Not applicable
- Decomposition temperature
- Not applicable
- Flammability (solid, gas)
- Not flammable under normal conditions
- Vapour pressure
- Not applicable
- Relative vapour density at 20°C
- Not applicable
- Density
- 1.1 g/cm³
- Solubility
- Freely soluble in water
- Log Pow
- Not applicable
- Viscosity, kinematic
- Not applicable
- Viscosity, dynamic
- Not applicable
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- Not applicable
10.1 — Reactivity
- Reactivity
- Stable under normal conditions.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizing agents.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- LD50 (oral, rat) 300 mg/kg
- Skin corrosion/irritation
- May cause skin irritation.
- Serious eye damage/irritation
- May cause eye irritation.
- Respiratory or skin sensitisation
- May cause allergic skin reactions in sensitive individuals.
- Germ cell mutagenicity
- Not classified
- Carcinogenicity
- Not classified
- Specific target organ toxicity (single exposure)
- May cause respiratory irritation.
- Specific target organ toxicity (repeated exposure)
- Not classified
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- UN 2811
- UN-No. (IMDG)
- UN 2811
- UN-No. (IATA)
- UN 2811
- UN-No. (ADN)
- UN 2811
- UN-No. (RID)
- UN 2811
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Toxic solid, organic, n.o.s. (Procaine Hydrochloride)
- Proper Shipping Name (IMDG)
- Toxic solid, organic, n.o.s. (Procaine Hydrochloride)
- Proper Shipping Name (IATA)
- Toxic solid, organic, n.o.s. (Procaine Hydrochloride)
- Proper Shipping Name (ADN)
- Toxic solid, organic, n.o.s. (Procaine Hydrochloride)
- Proper Shipping Name (RID)
- Toxic solid, organic, n.o.s. (Procaine Hydrochloride)
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 6.1
14.4 — Packing group
- Packing group (ADR)
- III
- Packing group (IMDG)
- III
- Packing group (IATA)
- III
- Packing group (ADN)
- III
- Packing group (RID)
- III
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Procaine hydrochloride is primarily used in the medical field as a local anesthetic, particularly in dental procedures and minor surgeries. It serves as a reference standard in pharmaceutical quality control, ensuring the efficacy and safety of local anesthetic formulations. Additionally, it is utilized in research settings to study the pharmacological effects of anesthetics and to develop new anesthetic agents. Its role in veterinary medicine is also notable, where it is used for local anesthesia in animals.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL02484
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 272.77 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay | 97% min | 97.5% |
| Melting Point | 170-175 °C | 172 °C |
| Moisture Content | 0.5% max | 0.3% |
| Residue on Ignition | 0.1% max | 0.05% |
| Related Substances | None detected | None detected |
| Solubility | Freely soluble in water | Freely soluble in water |
The above product is expected to comply with 97% Extra Pure grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| 97% Extra Pure | 97% min | 170-175 °C | 0.5% max | 0.1% max | None detected | Freely soluble in water |
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