Proflavine hemisulfate dihydrate
- CAS Number
- 1811-28-5
- HSN Code
- 29335990
- Molecular Formula
- (C13H11N3)2·H2SO4·2H2O
- Catalogue Number
- AL2485C
- Purity
- ≥ 98%
- Molecular Weight
- 552.62 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Proflavine hemisulfate dihydrate (extra pure, 3,6-diaminoacridine hemisulfate) is an acridine dye that has been historically utilized as a topical antiseptic and is recognized for its role as a DNA-intercalating agent in various research applications. This compound is notable for its bright orange-yellow color and its ability to bind to DNA, making it valuable in molecular biology studies, particularly in mutagenesis research. The extra pure grade ensures high quality and minimal impurities, which is essential for sensitive applications. Proflavine hemisulfate dihydrate is also of interest in the study of antimicrobial properties and has been used in historical antiseptic pharmaceutical formulations.
Also known as 3,6-Diaminoacridine hemisulfate.
- Catalogue No.
- AL2485C
- CAS Number
- 1811-28-5
- Molecular Formula
- (C13H11N3)2·H2SO4·2H2O
- Molecular Weight
- 552.62 g/mol
- HSN Code
- 29335990
- Grade
- Extra Pure
- Product Form
- Substance
Proflavine hemisulfate dihydrate appears as an orange-yellow crystalline powder. It has a molecular weight of 552.62 g/mol and is soluble in water, allowing for easy preparation of solutions for laboratory use. The melting point of proflavine hemisulfate dihydrate is approximately 220 °C (decomposes), and it has a density of about 1.5 g/cm³. The compound has a pH value in solution of around 4.5 to 6.0, indicating its mildly acidic nature. Its solubility in water is significant, facilitating its use in various aqueous applications.
- Appearance
- Orange-yellow crystalline powder
- Shelf Life
- 2 years
- Packaging
- Available in 100 g and 500 g glass bottles
- Storage
- Store in a cool, dry place, away from light.
1.1 — Product identifier
- Chemical Name
- Proflavine hemisulfate dihydrate
- Catalogue No.
- AL2485C
- Product form
- Substance
- CAS Number
- 1811-28-5
- EC Number
- N/A
- Grade
- Extra Pure
- EC Index Number
- N/A
- Chemical Formula
- (C13H11N3)2·H2SO4·2H2O
- HSN Code
- 29335990
- Synonyms
- 3,6-Diaminoacridine hemisulfate
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Research and laboratory applications, historical antiseptic
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.3 — Other hazards
- Other hazards
- May cause skin and eye irritation
3.1 — Substance
- Name
- Proflavine hemisulfate dihydrate
- CAS No.
- 1811-28-5
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- Wash with soap and water. If irritation occurs, seek medical attention.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing and seek medical attention.
- First-aid measures after ingestion
- Rinse mouth. Do not induce vomiting. Seek medical attention if symptoms occur.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Irritation of skin, eyes, and respiratory tract.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- May emit toxic fumes under fire conditions.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Contain spill and collect using appropriate protective equipment. Dispose of in accordance with local regulations.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Use appropriate personal protective equipment. Sweep up and place in a suitable container for disposal.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Avoid contact with skin and eyes. Use in a well-ventilated area.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Store in a cool, dry place, away from incompatible materials.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respiratory protection if dust is generated.
9.1 — Information on basic physical and chemical properties
- Physical state
- Solid
- Colour
- Orange-yellow
- Odour
- Odourless
- Odour threshold
- Not applicable
- pH value
- 4.5 - 6.0
- Relative evaporation rate (butylacetate=1)
- Not applicable
- Melting point
- 220 °C (decomposes)
- Freezing point
- Not applicable
- Boiling point
- Not applicable
- Flash point
- Not applicable
- Auto-ignition temperature
- Not applicable
- Decomposition temperature
- 220 °C
- Flammability (solid, gas)
- Not flammable
- Vapour pressure
- Not applicable
- Relative vapour density at 20°C
- Not applicable
- Density
- 1.5 g/cm³
- Solubility
- Soluble in water
- Log Pow
- Not applicable
- Viscosity, kinematic
- Not applicable
- Viscosity, dynamic
- Not applicable
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- Not applicable
10.1 — Reactivity
- Reactivity
- Stable under normal conditions, but may react with strong oxidizing agents.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizing agents, strong acids.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- LD50 (oral, rat) > 2000 mg/kg.
- Skin corrosion/irritation
- May cause mild irritation.
- Serious eye damage/irritation
- May cause irritation.
- Respiratory or skin sensitisation
- Not a sensitizer.
- Germ cell mutagenicity
- Not classified
- Carcinogenicity
- Not classified
- Specific target organ toxicity (single exposure)
- Not classified as a specific target organ toxicant.
- Specific target organ toxicity (repeated exposure)
- Not classified
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- Not assigned
- UN-No. (IMDG)
- Not assigned
- UN-No. (IATA)
- Not assigned
- UN-No. (ADN)
- Not assigned
- UN-No. (RID)
- Not assigned
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Not classified as dangerous goods
- Proper Shipping Name (IMDG)
- Not classified as dangerous goods
- Proper Shipping Name (IATA)
- Not classified as dangerous goods
- Proper Shipping Name (ADN)
- Not classified as dangerous goods
- Proper Shipping Name (RID)
- Not classified as dangerous goods
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- Not applicable
14.4 — Packing group
- Packing group (ADR)
- Not applicable
- Packing group (IMDG)
- Not applicable
- Packing group (IATA)
- Not applicable
- Packing group (ADN)
- Not applicable
- Packing group (RID)
- Not applicable
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Proflavine hemisulfate dihydrate is primarily used as a DNA-intercalating agent in molecular biology and genetic research, where it aids in the study of DNA structure and function. It has applications in mutagenesis studies, where it is used to induce mutations in DNA for research purposes. Historically, it has been employed as a topical antiseptic in the treatment of wounds and infections due to its antimicrobial properties. Additionally, it is used in the development of staining techniques in microbiology and histology, allowing for the visualization of cellular structures. Its unique properties also make it a candidate for further research in drug development and therapeutic applications.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL2485C
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 552.62 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay | ≥ 98% | 99.5% |
| Moisture Content | ≤ 1% | 0.5% |
| Residue on Ignition | ≤ 0.5% | 0.3% |
| Related Substances | None detected | None detected |
| Solubility | Soluble in water | Fully soluble |
The above product is expected to comply with Extra Pure grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| Extra Pure | ≥ 98% | 220 °C (decomposes) | ≤ 1% | ≤ 0.5% | None detected | Soluble in water |
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