Propionic Anhydride
- CAS Number
- 123-62-6
- HSN Code
- 29155000
- Molecular Formula
- C6H10O3
- Catalogue Number
- AL1270A
- Purity
- ≥ 98%
- Molecular Weight
- 130.14 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Propionic anhydride (for synthesis) is the anhydride of propionic acid, serving as a vital acylating reagent in organic synthesis. This compound is particularly notable for its role in the formation of propionyl derivatives, which are essential in various chemical reactions. With a purity of 98%, it is suitable for high-level synthesis applications in both academic and industrial settings. Propionic anhydride is recognized for its reactivity and is commonly utilized in the synthesis of pharmaceuticals and agrochemicals.
Also known as Propanoic anhydride.
- Catalogue No.
- AL1270A
- CAS Number
- 123-62-6
- Molecular Formula
- C6H10O3
- Molecular Weight
- 130.14 g/mol
- HSN Code
- 29155000
- Grade
- 98%
- Product Form
- Substance
Propionic anhydride is a colorless liquid with a density of 1.015 g/mL. It has a pungent odor characteristic of anhydrides, which can be irritating to the respiratory system. The boiling point of propionic anhydride is approximately 164 °C, and it has a melting point of -20 °C. It is soluble in organic solvents such as ether and chloroform but reacts with water, forming propionic acid. The flash point is 60 °C, indicating that it is flammable under certain conditions.
- Appearance
- Colorless liquid
- Shelf Life
- 12 months
- Packaging
- Available in 1L and 5L glass bottles
- Storage
- Store in a cool, dry place away from moisture and incompatible materials.
1.1 — Product identifier
- Chemical Name
- Propionic Anhydride
- Catalogue No.
- AL1270A
- Product form
- Substance
- CAS Number
- 123-62-6
- EC Number
- 204-634-3
- Grade
- 98%
- EC Index Number
- 607-007-00-8
- Chemical Formula
- C6H10O3
- HSN Code
- 29155000
- Synonyms
- Propanoic anhydride
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Acylating reagent in organic synthesis
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.3 — Other hazards
- Other hazards
- Corrosive to metals
3.1 — Substance
- Name
- Propionic Anhydride
- CAS No.
- 123-62-6
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- Wash with plenty of soap and water. Seek medical attention if irritation develops.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing and seek medical attention.
- First-aid measures after ingestion
- Do not induce vomiting. Rinse mouth and seek medical attention immediately.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Irritation of the skin, eyes, and respiratory tract; potential burns on contact.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- Combustible liquid; may produce toxic fumes in a fire.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Evacuate area and ventilate. Contain spill and absorb with inert material.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Collect and dispose of in accordance with local regulations.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Use in a fume hood with appropriate personal protective equipment (PPE).
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Store in tightly closed containers in a cool, dry, well-ventilated area.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respiratory protection if ventilation is inadequate.
9.1 — Information on basic physical and chemical properties
- Physical state
- Liquid
- Colour
- Colorless
- Odour
- Pungent
- Odour threshold
- No data available
- pH value
- No data available
- Relative evaporation rate (butylacetate=1)
- No data available
- Melting point
- -20 °C
- Freezing point
- No data available
- Boiling point
- 164 °C
- Flash point
- 60 °C
- Auto-ignition temperature
- No data available
- Decomposition temperature
- No data available
- Flammability (solid, gas)
- Flammable liquid
- Vapour pressure
- 0.5 mmHg at 20 °C
- Relative vapour density at 20°C
- No data available
- Density
- 1.015 g/mL
- Solubility
- Reacts with water; soluble in organic solvents
- Log Pow
- No data available
- Viscosity, kinematic
- No data available
- Viscosity, dynamic
- No data available
- Explosive properties
- No data available
- Oxidising properties
- No data available
- Explosive limits
- No data available
10.1 — Reactivity
- Reactivity
- Reacts violently with water, releasing heat and forming propionic acid.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Water, strong oxidizing agents, strong bases.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- LD50 (oral, rat) > 2000 mg/kg; may cause burns.
- Skin corrosion/irritation
- Causes skin irritation; may cause burns.
- Serious eye damage/irritation
- Causes serious eye damage.
- Respiratory or skin sensitisation
- May cause allergic skin reaction in sensitive individuals.
- Germ cell mutagenicity
- Not classified
- Carcinogenicity
- Not classified
- Specific target organ toxicity (single exposure)
- May cause respiratory irritation.
- Specific target organ toxicity (repeated exposure)
- Not classified
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- UN 2496
- UN-No. (IMDG)
- UN 2496
- UN-No. (IATA)
- UN 2496
- UN-No. (ADN)
- UN 2496
- UN-No. (RID)
- UN 2496
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Propionic anhydride
- Proper Shipping Name (IMDG)
- Propionic anhydride
- Proper Shipping Name (IATA)
- Propionic anhydride
- Proper Shipping Name (ADN)
- Propionic anhydride
- Proper Shipping Name (RID)
- Propionic anhydride
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 8
14.4 — Packing group
- Packing group (ADR)
- III
- Packing group (IMDG)
- III
- Packing group (IATA)
- III
- Packing group (ADN)
- III
- Packing group (RID)
- III
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Propionic anhydride is widely used as a propionylating agent in organic synthesis, particularly in the pharmaceutical industry for the synthesis of propionyl derivatives of various compounds. It is also employed in the production of agrochemicals and in the preparation of esters and amides. Additionally, it finds applications in the synthesis of flavoring agents and fragrances, as well as in polymer chemistry for modifying polymer properties. Its versatility makes it a valuable reagent in both research and industrial applications.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL1270A
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 130.14 g/mol
| Test | Standard | Observed |
|---|---|---|
| Description | Clear colorless liquid | Clear colorless liquid |
| Assay (GC) | Min. 98.0% | 98.28% |
| Density (d 20°C/4°C) | 1.009 - 1.011 | 1.010 |
| Refractive index n20 o/D | About 1.4040 | 1.4040 |
The above product complies with LR grade
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| 98% | ≥ 98% | -20 °C / 164 °C | ≤ 0.5% | ≤ 0.1% | None detected | Soluble in organic solvents, reacts with water |
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