Propranolol Hydrochloride
- CAS Number
- 318-98-9
- HSN Code
- 29181190
- Molecular Formula
- C16H21NO2·HCl
- Catalogue Number
- AL2486C
- Purity
- 99%
- Molecular Weight
- 295.80 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Propranolol hydrochloride (extra pure) is a widely used beta-blocker drug primarily indicated for the management of hypertension, angina pectoris, and various types of arrhythmias. It functions by blocking beta-adrenergic receptors, leading to a decrease in heart rate and myocardial contractility. This compound is notable for its high purity level of 99%, making it suitable for laboratory use and pharmaceutical applications. Propranolol hydrochloride is also utilized in the treatment of anxiety and migraine prophylaxis, showcasing its versatility in clinical settings.
Also known as Propranolol HCl, Inderal.
- Catalogue No.
- AL2486C
- CAS Number
- 318-98-9
- Molecular Formula
- C16H21NO2·HCl
- Molecular Weight
- 295.80 g/mol
- HSN Code
- 29181190
- Grade
- Extra Pure
- Product Form
- Substance
Propranolol hydrochloride appears as a white crystalline powder with a characteristic odor. It has a melting point of approximately 177-180 °C and is freely soluble in water, which facilitates its use in various formulations. The compound has a density of about 1.1 g/cm³ and a pH value in solution typically ranging from 4.5 to 6.5. Its solubility in organic solvents is limited, making it primarily water-soluble for pharmaceutical applications.
- Appearance
- White crystalline powder
- Shelf Life
- 2 years
- Packaging
- Available in 100 g and 500 g containers
- Storage
- Store in a cool, dry place, away from light.
1.1 — Product identifier
- Chemical Name
- Propranolol Hydrochloride
- Catalogue No.
- AL2486C
- Product form
- Substance
- CAS Number
- 318-98-9
- EC Number
- 206-202-0
- Grade
- Extra Pure
- EC Index Number
- 607-007-00-0
- Chemical Formula
- C16H21NO2·HCl
- HSN Code
- 29181190
- Synonyms
- Propranolol HCl, Inderal
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Pharmaceutical reference standard
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.3 — Other hazards
- Other hazards
- None identified
3.1 — Substance
- Name
- Propranolol Hydrochloride
- CAS No.
- 318-98-9
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- Wash with soap and water. If irritation occurs, seek medical attention.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. If irritation persists, seek medical attention.
- First-aid measures after ingestion
- Rinse mouth. Do not induce vomiting. Seek medical attention immediately.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Dizziness, fatigue, bradycardia, hypotension.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- May emit toxic fumes under fire conditions.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Contain spill and collect using appropriate protective equipment. Dispose of in accordance with local regulations.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Use appropriate personal protective equipment. Sweep up and place in a suitable container for disposal.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Handle with gloves and avoid contact with skin and eyes. Use in a well-ventilated area.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Store in a tightly closed container in a cool, dry place.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respiratory protection if dust is generated.
9.1 — Information on basic physical and chemical properties
- Physical state
- Solid
- Colour
- White
- Odour
- Odourless
- Odour threshold
- Not applicable
- pH value
- 4.5 - 6.5 (in solution)
- Relative evaporation rate (butylacetate=1)
- Not applicable
- Melting point
- 177-180 °C
- Freezing point
- Not applicable
- Boiling point
- Not applicable
- Flash point
- Not applicable
- Auto-ignition temperature
- Not applicable
- Decomposition temperature
- Not applicable
- Flammability (solid, gas)
- Not flammable
- Vapour pressure
- Not applicable
- Relative vapour density at 20°C
- Not applicable
- Density
- 1.1 g/cm³
- Solubility
- Freely soluble in water
- Log Pow
- Not applicable
- Viscosity, kinematic
- Not applicable
- Viscosity, dynamic
- Not applicable
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- Not applicable
10.1 — Reactivity
- Reactivity
- Stable under normal conditions.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizing agents.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- LD50 (oral, rat) > 2000 mg/kg.
- Skin corrosion/irritation
- Not irritating to skin.
- Serious eye damage/irritation
- May cause mild irritation.
- Respiratory or skin sensitisation
- Not a sensitizer.
- Germ cell mutagenicity
- Not classified
- Carcinogenicity
- Not classified
- Specific target organ toxicity (single exposure)
- Not classified as a specific target organ toxicant.
- Specific target organ toxicity (repeated exposure)
- Not classified
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- Not assigned
- UN-No. (IMDG)
- Not assigned
- UN-No. (IATA)
- Not assigned
- UN-No. (ADN)
- Not assigned
- UN-No. (RID)
- Not assigned
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Not regulated
- Proper Shipping Name (IMDG)
- Not regulated
- Proper Shipping Name (IATA)
- Not regulated
- Proper Shipping Name (ADN)
- Not regulated
- Proper Shipping Name (RID)
- Not regulated
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- Not applicable
14.4 — Packing group
- Packing group (ADR)
- Not applicable
- Packing group (IMDG)
- Not applicable
- Packing group (IATA)
- Not applicable
- Packing group (ADN)
- Not applicable
- Packing group (RID)
- Not applicable
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Propranolol hydrochloride is extensively used as a reference standard in pharmaceutical quality control, particularly in the development and testing of cardiovascular beta-blocker medications. It is also employed in clinical research to study its effects on hypertension and anxiety disorders. Additionally, this compound is utilized in the formulation of various dosage forms, including tablets and injectable solutions, due to its pharmacological properties. Its role in migraine prophylaxis further expands its application in neurology and pain management.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL2486C
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 295.80 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay | 99% min | 99.5% |
| Moisture Content | <0.5% | 0.3% |
| Residue on Ignition | <0.1% | 0.05% |
| Related Substances | None detected | None detected |
| Solubility | Freely soluble in water | Freely soluble in water |
The above product is expected to comply with Extra Pure grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| Extra Pure | 99% | 177-180 °C | <0.5% | <0.1% | None detected | Freely soluble in water |
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