Quinine Sulfate Dihydrate
- CAS Number
- 6119-70-6
- HSN Code
- 29392030
- Molecular Formula
- (C20H24N2O2)2·H2SO4·2H2O
- Catalogue Number
- AL1285A
- Purity
- 99%
- Molecular Weight
- 782.96 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Quinine sulfate dihydrate (extra pure) is a pharmaceutical-grade alkaloid salt derived from the bark of the cinchona tree. It is primarily recognized for its antimalarial properties and is utilized as a reference standard in pharmaceutical quality control. This compound is notable for its high purity level of 99%, making it suitable for sensitive analytical applications. Quinine sulfate dihydrate is also used in research settings for its fluorescence properties, contributing to its importance in various scientific studies.
Also known as Quinine sulfate, Quinine sulfate dihydrate.
- Catalogue No.
- AL1285A
- CAS Number
- 6119-70-6
- Molecular Formula
- (C20H24N2O2)2·H2SO4·2H2O
- Molecular Weight
- 782.96 g/mol
- HSN Code
- 29392030
- Grade
- Extra Pure
- Product Form
- Substance
Quinine sulfate dihydrate appears as a white crystalline powder with a characteristic bitter taste. It has a melting point of approximately 174-176 °C and is sparingly soluble in cold water, with a solubility of about 0.5 g/L at 25 °C. The compound has a density of approximately 1.5 g/cm³. Its solubility increases in hot water, making it more accessible for various applications. The compound is stable under normal conditions but should be stored in a cool, dry place to maintain its integrity.
- Appearance
- White crystalline powder
- Shelf Life
- 2 years
- Packaging
- Available in 25 g and 100 g glass bottles
- Storage
- Store in a cool, dry place, away from light.
1.1 — Product identifier
- Chemical Name
- Quinine Sulfate Dihydrate
- Catalogue No.
- AL1285A
- Product form
- Substance
- CAS Number
- 6119-70-6
- EC Number
- 228-202-0
- Grade
- Extra Pure
- EC Index Number
- Not applicable
- Chemical Formula
- (C20H24N2O2)2·H2SO4·2H2O
- HSN Code
- 29392030
- Synonyms
- Quinine sulfate, Quinine sulfate dihydrate
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Pharmaceutical reference standard, antimalarial research
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.3 — Other hazards
- Other hazards
- Pharmacologically active compound; handle with care.
3.1 — Substance
- Name
- Quinine Sulfate Dihydrate
- CAS No.
- 6119-70-6
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- Wash with soap and water. If irritation occurs, seek medical attention.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. If irritation persists, seek medical attention.
- First-aid measures after ingestion
- Rinse mouth. Do not induce vomiting. Seek medical attention if symptoms occur.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Headache, dizziness, nausea, and gastrointestinal discomfort may occur upon exposure.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- May emit toxic fumes under fire conditions.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Contain spill and collect using appropriate protective equipment. Dispose of in accordance with local regulations.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Use appropriate personal protective equipment. Sweep up and place in a suitable container for disposal.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Avoid contact with skin and eyes. Use gloves and safety goggles when handling.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Store in a cool, dry place, away from incompatible materials.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use in a well-ventilated area. If exposure limits are exceeded, use appropriate respiratory protection.
9.1 — Information on basic physical and chemical properties
- Physical state
- Solid
- Colour
- White
- Odour
- Odourless
- Odour threshold
- Not applicable
- pH value
- Not applicable
- Relative evaporation rate (butylacetate=1)
- Not applicable
- Melting point
- 174-176 °C
- Freezing point
- Not applicable
- Boiling point
- Not applicable
- Flash point
- Not applicable
- Auto-ignition temperature
- Not applicable
- Decomposition temperature
- Not applicable
- Flammability (solid, gas)
- Not flammable
- Vapour pressure
- Not applicable
- Relative vapour density at 20°C
- Not applicable
- Density
- 1.5 g/cm³
- Solubility
- Sparingly soluble in cold water, soluble in hot water
- Log Pow
- Not applicable
- Viscosity, kinematic
- Not applicable
- Viscosity, dynamic
- Not applicable
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- Not applicable
10.1 — Reactivity
- Reactivity
- Stable under normal conditions; avoid strong acids and bases.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizing agents, strong acids, and bases.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- LD50 (oral, rat) = 200 mg/kg
- Skin corrosion/irritation
- May cause skin irritation in sensitive individuals.
- Serious eye damage/irritation
- May cause eye irritation.
- Respiratory or skin sensitisation
- May cause allergic skin reactions in sensitive individuals.
- Germ cell mutagenicity
- Not classified
- Carcinogenicity
- Not classified
- Specific target organ toxicity (single exposure)
- Not classified as a specific target organ toxicant.
- Specific target organ toxicity (repeated exposure)
- Not classified
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- Not assigned
- UN-No. (IMDG)
- Not assigned
- UN-No. (IATA)
- Not assigned
- UN-No. (ADN)
- Not assigned
- UN-No. (RID)
- Not assigned
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Not classified as dangerous goods
- Proper Shipping Name (IMDG)
- Not classified as dangerous goods
- Proper Shipping Name (IATA)
- Not classified as dangerous goods
- Proper Shipping Name (ADN)
- Not classified as dangerous goods
- Proper Shipping Name (RID)
- Not classified as dangerous goods
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- Not applicable
14.4 — Packing group
- Packing group (ADR)
- Not applicable
- Packing group (IMDG)
- Not applicable
- Packing group (IATA)
- Not applicable
- Packing group (ADN)
- Not applicable
- Packing group (RID)
- Not applicable
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Quinine sulfate dihydrate is extensively used as a reference standard in pharmaceutical quality control, particularly in the development and testing of antimalarial drugs. It serves as a critical component in fluorescence quantum-yield standardization, which is essential for accurate measurements in photophysical studies. Additionally, it is employed in various research applications, including studies on drug interactions and pharmacokinetics. The compound's unique properties also make it valuable in the formulation of certain beverages, where it is used to impart a bitter flavor.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL1285A
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 782.96 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay | 99% purity | 99.5% |
| Melting Point | 174-176 °C | 175 °C |
| Moisture Content | <1% | 0.5% |
| Residue on Ignition | <0.1% | 0.05% |
| Related Substances | None detected | None detected |
The above product is expected to comply with Extra Pure grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| Extra Pure | 99% | 174-176 °C | <1% | <0.1% | None detected | Sparingly soluble in cold water, soluble in hot water |
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