Ribonuclease A
- CAS Number
- 9001-99-4
- HSN Code
- 35079099
- Molecular Formula
- C14H19N3O5P
- Catalogue Number
- AL2494B
- Purity
- ≥ 95%
- Molecular Weight
- 13700 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Ribonuclease A (RNase A) is a ribonuclease enzyme derived from bovine pancreas, known for its ability to catalyze the degradation of RNA into smaller oligonucleotides and nucleotides. It is one of the most extensively studied enzymes in biochemistry, making it a vital tool in molecular biology and biochemistry research. RNase A is particularly notable for its specificity towards single-stranded RNA, which makes it invaluable in applications requiring the removal of RNA contamination from DNA preparations. With a molecular weight of 13,700 g/mol, RNase A is classified as an enzyme protein, and its CAS number is 9001-99-4.
Also known as RNase A, Ribonuclease, Rnase A.
- Catalogue No.
- AL2494B
- CAS Number
- 9001-99-4
- Molecular Formula
- C14H19N3O5P
- Molecular Weight
- 13700 g/mol
- HSN Code
- 35079099
- Grade
- Biochemical grade
- Product Form
- Substance
Ribonuclease A appears as a white to off-white powder. It is soluble in buffer solutions, which is essential for its activity in biochemical applications. The enzyme exhibits a melting point of approximately 70-75 °C, and it is stable under a wide range of pH conditions, typically between pH 5 and 9. RNase A has a density of about 1.2 g/cm³ and is hygroscopic, meaning it can absorb moisture from the air, which should be considered during storage and handling.
- Appearance
- White to off-white powder
- Shelf Life
- 2 years when stored properly
- Packaging
- Available in 1g and 5g vials
- Storage
- Store at -20 °C for long-term storage; avoid repeated freeze-thaw cycles.
1.1 — Product identifier
- Chemical Name
- Ribonuclease A
- Catalogue No.
- AL2494B
- Product form
- Substance
- CAS Number
- 9001-99-4
- EC Number
- 232-940-0
- Grade
- Biochemical grade
- EC Index Number
- Not applicable
- Chemical Formula
- C14H19N3O5P
- HSN Code
- 35079099
- Synonyms
- RNase A, Ribonuclease, Rnase A
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Biochemical research, RNA degradation
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.3 — Other hazards
- Other hazards
- None known
3.1 — Substance
- Name
- Ribonuclease A
- CAS No.
- 9001-99-4
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- Wash with soap and water. If irritation occurs, seek medical attention.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. If irritation persists, seek medical attention.
- First-aid measures after ingestion
- Rinse mouth. Do not induce vomiting. Seek medical attention if symptoms occur.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- May cause mild irritation to skin, eyes, and respiratory tract.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- Non-flammable; however, combustion may produce toxic fumes.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Contain spill and collect using appropriate protective equipment. Dispose of in accordance with local regulations.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Use appropriate personal protective equipment. Clean up spills with absorbent material and dispose of properly.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Avoid contact with skin and eyes. Use in a well-ventilated area. Wear appropriate protective equipment.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Store in a cool, dry place, away from moisture and incompatible materials.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Not required under normal conditions of use; use in a well-ventilated area.
9.1 — Information on basic physical and chemical properties
- Physical state
- Solid
- Colour
- White to off-white
- Odour
- Odourless
- Odour threshold
- Not applicable
- pH value
- Not applicable
- Relative evaporation rate (butylacetate=1)
- Not applicable
- Melting point
- 70-75 °C
- Freezing point
- Not applicable
- Boiling point
- Not applicable
- Flash point
- Not applicable
- Auto-ignition temperature
- Not applicable
- Decomposition temperature
- Not applicable
- Flammability (solid, gas)
- Not flammable
- Vapour pressure
- Not applicable
- Relative vapour density at 20°C
- Not applicable
- Density
- 1.2 g/cm³
- Solubility
- Soluble in buffer solutions
- Log Pow
- Not applicable
- Viscosity, kinematic
- Not applicable
- Viscosity, dynamic
- Not applicable
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- Not applicable
10.1 — Reactivity
- Reactivity
- Stable under normal conditions; avoid strong oxidizing agents.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizing agents, strong acids, and bases.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- Not classified as acutely toxic.
- Skin corrosion/irritation
- May cause mild irritation.
- Serious eye damage/irritation
- May cause mild irritation.
- Respiratory or skin sensitisation
- Not expected to be a sensitizer.
- Germ cell mutagenicity
- Not classified
- Carcinogenicity
- Not classified
- Specific target organ toxicity (single exposure)
- Not classified as a specific target organ toxicant.
- Specific target organ toxicity (repeated exposure)
- Not classified
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- Not classified as dangerous goods.
- UN-No. (IMDG)
- Not classified as dangerous goods.
- UN-No. (IATA)
- Not classified as dangerous goods.
- UN-No. (ADN)
- Not classified as dangerous goods.
- UN-No. (RID)
- Not classified as dangerous goods.
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Not applicable
- Proper Shipping Name (IMDG)
- Not applicable
- Proper Shipping Name (IATA)
- Not applicable
- Proper Shipping Name (ADN)
- Not applicable
- Proper Shipping Name (RID)
- Not applicable
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- Not applicable
14.4 — Packing group
- Packing group (ADR)
- Not applicable
- Packing group (IMDG)
- Not applicable
- Packing group (IATA)
- Not applicable
- Packing group (ADN)
- Not applicable
- Packing group (RID)
- Not applicable
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Ribonuclease A is widely used in molecular biology laboratories for the removal of contaminating RNA from DNA preparations, which is crucial for applications such as PCR and cloning. Additionally, it serves as a classic model enzyme for studying protein folding and enzyme kinetics in biochemistry research. RNase A is also utilized in various diagnostic assays and therapeutic applications, including the development of RNA-targeting drugs and in the study of RNA metabolism. Its role in RNA degradation makes it a key component in RNA purification protocols.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL2494B
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 13700 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay Purity | ≥ 95% | 96.5% |
| Moisture Content | ≤ 5% | 3.2% |
| Residue on Ignition | ≤ 1% | 0.5% |
| Related Substances | None detected | None detected |
| Solubility | Soluble in buffer solutions | Fully soluble in 0.1 M phosphate buffer |
The above product is expected to comply with Biochemical grade grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| Biochemical grade | ≥ 95% | 70-75 °C | ≤ 5% | ≤ 1% | None detected | Soluble in buffer solutions |
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“Speedy delivery, professional staff.”
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