Rifampicin
- CAS Number
- 13292-46-1
- HSN Code
- 29339900
- Molecular Formula
- C43H58N4O12
- Catalogue Number
- AL2495B
- Purity
- 97%
- Molecular Weight
- 822.94 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Rifampicin (for biochemistry) is a first-line antituberculosis antibiotic that inhibits bacterial RNA polymerase, making it a crucial agent in the treatment of tuberculosis and other bacterial infections. It is particularly effective against Mycobacterium tuberculosis and is often used in combination with other antibiotics to prevent resistance. This compound is notable for its ability to penetrate bacterial cells and disrupt RNA synthesis, which is essential for bacterial growth and reproduction. The high purity grade of 97% ensures its suitability for biochemical applications and research.
Also known as Rifampin, Rifampin, Rifampicine.
- Catalogue No.
- AL2495B
- CAS Number
- 13292-46-1
- Molecular Formula
- C43H58N4O12
- Molecular Weight
- 822.94 g/mol
- HSN Code
- 29339900
- Grade
- For Biochemistry
- Product Form
- Substance
Rifampicin appears as an orange-red crystalline powder that is light-sensitive, requiring careful handling to maintain its stability. It has a melting point of approximately 180-182 °C and is slightly soluble in water, with a solubility of about 0.1 g/L at 25 °C. The compound has a density of approximately 1.3 g/cm³. Its solubility profile indicates that it is more soluble in organic solvents such as ethanol and acetone, which is important for its application in laboratory settings.
- Appearance
- Orange-red crystalline powder
- Shelf Life
- 2 years
- Packaging
- 25 g in amber glass bottles
- Storage
- Store in a cool, dry place, protected from light.
1.1 — Product identifier
- Chemical Name
- Rifampicin
- Catalogue No.
- AL2495B
- Product form
- Substance
- CAS Number
- 13292-46-1
- EC Number
- 236-120-0
- Grade
- For Biochemistry
- EC Index Number
- Not applicable
- Chemical Formula
- C43H58N4O12
- HSN Code
- 29339900
- Synonyms
- Rifampin, Rifampin, Rifampicine
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Antibiotic, RNA polymerase inhibitor
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.3 — Other hazards
- Other hazards
- Light-sensitive, handle with care
3.1 — Substance
- Name
- Rifampicin
- CAS No.
- 13292-46-1
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- Wash with soap and water. If irritation occurs, seek medical attention.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. If irritation persists, seek medical attention.
- First-aid measures after ingestion
- Do not induce vomiting. Rinse mouth and seek medical attention immediately.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- May cause skin irritation, respiratory issues, or gastrointestinal discomfort upon exposure.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- Combustible material; may produce toxic fumes when burned.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Contain spill and collect using appropriate protective equipment. Dispose of in accordance with local regulations.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Use appropriate personal protective equipment. Clean up spills immediately and dispose of waste properly.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Handle with gloves and avoid exposure to light. Use in a well-ventilated area.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Store in a cool, dry place, away from light and moisture.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respiratory protection if dust is generated.
9.1 — Information on basic physical and chemical properties
- Physical state
- Solid
- Colour
- Orange-red
- Odour
- Odourless
- Odour threshold
- Not applicable
- pH value
- Not applicable
- Relative evaporation rate (butylacetate=1)
- Not applicable
- Melting point
- 180-182 °C
- Freezing point
- Not applicable
- Boiling point
- Not applicable
- Flash point
- Not applicable
- Auto-ignition temperature
- Not applicable
- Decomposition temperature
- Not applicable
- Flammability (solid, gas)
- Not flammable under normal conditions
- Vapour pressure
- Not applicable
- Relative vapour density at 20°C
- Not applicable
- Density
- 1.3 g/cm³
- Solubility
- Slightly soluble in water, soluble in ethanol and acetone
- Log Pow
- Not applicable
- Viscosity, kinematic
- Not applicable
- Viscosity, dynamic
- Not applicable
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- Not applicable
10.1 — Reactivity
- Reactivity
- Stable under normal conditions, but sensitive to light.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizing agents, strong acids, and bases.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- LD50 (oral, rat) > 2000 mg/kg; low acute toxicity.
- Skin corrosion/irritation
- May cause mild skin irritation.
- Serious eye damage/irritation
- May cause mild eye irritation.
- Respiratory or skin sensitisation
- Not a sensitizer in animal studies.
- Germ cell mutagenicity
- Not classified
- Carcinogenicity
- Not classified
- Specific target organ toxicity (single exposure)
- Not classified as a specific target organ toxicant.
- Specific target organ toxicity (repeated exposure)
- Not classified
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- Not assigned
- UN-No. (IMDG)
- Not assigned
- UN-No. (IATA)
- Not assigned
- UN-No. (ADN)
- Not assigned
- UN-No. (RID)
- Not assigned
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Not classified as dangerous goods
- Proper Shipping Name (IMDG)
- Not classified as dangerous goods
- Proper Shipping Name (IATA)
- Not classified as dangerous goods
- Proper Shipping Name (ADN)
- Not classified as dangerous goods
- Proper Shipping Name (RID)
- Not classified as dangerous goods
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- Not applicable
14.4 — Packing group
- Packing group (ADR)
- Not applicable
- Packing group (IMDG)
- Not applicable
- Packing group (IATA)
- Not applicable
- Packing group (ADN)
- Not applicable
- Packing group (RID)
- Not applicable
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Rifampicin is widely used as a reference standard in pharmaceutical quality control, ensuring the accuracy and reliability of drug formulations. In molecular biology research, it serves as an RNA polymerase inhibitor, allowing scientists to study gene expression and transcription processes. Additionally, it is utilized in the development of antibiotic susceptibility testing methods and in the formulation of combination therapies for tuberculosis treatment. Its role in research extends to studies on bacterial resistance mechanisms and the development of new antimicrobial agents.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL2495B
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 822.94 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay (Purity) | 97% min | 97.5% |
| Melting Point | 180-182 °C | 181 °C |
| Moisture Content | <1% | 0.5% |
| Residue on Ignition | <0.1% | 0.05% |
| Related Substances | <0.5% | 0.3% |
The above product is expected to comply with For Biochemistry grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| For Biochemistry | 97% | 180-182 °C | <1% | <0.1% | <0.5% | Slightly soluble in water, soluble in ethanol and acetone |
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