Silymarin
- CAS Number
- 65666-07-1
- HSN Code
- 29329900
- Molecular Formula
- C25H22O10
- Catalogue Number
- AL2502A
- Purity
- ≥ 70%
- Molecular Weight
- 482.44 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Silymarin is a natural flavonolignan complex extracted from the seeds of the milk thistle plant (Silybum marianum). It is primarily composed of silybin, silydianin, and silychristin, which are known for their hepatoprotective properties. Silymarin has been extensively studied for its potential to protect the liver from toxins and promote liver health. This compound is often used in dietary supplements and herbal remedies aimed at supporting liver function and overall health.
Also known as Milk Thistle Extract.
- Catalogue No.
- AL2502A
- CAS Number
- 65666-07-1
- Molecular Formula
- C25H22O10
- Molecular Weight
- 482.44 g/mol
- HSN Code
- 29329900
- Grade
- Standard grade
- Product Form
- Substance
Silymarin appears as a pale yellow to tan powder. It has a slightly bitter taste and is slightly soluble in water, with solubility increasing in alcohol and other organic solvents. The melting point of silymarin is not well-defined due to its complex nature, but it is stable under normal storage conditions. The density of silymarin is approximately 1.2 g/cm³. It has a molecular weight of 482.44 g/mol, and its chemical structure includes multiple hydroxyl groups contributing to its antioxidant properties.
- Appearance
- Pale yellow to tan powder
- Shelf Life
- 2 years
- Packaging
- Available in 100 g and 500 g containers
- Storage
- Store in a cool, dry place, away from light.
1.1 — Product identifier
- Chemical Name
- Silymarin
- Catalogue No.
- AL2502A
- Product form
- Substance
- CAS Number
- 65666-07-1
- EC Number
- N/A
- Grade
- Standard grade
- EC Index Number
- N/A
- Chemical Formula
- C25H22O10
- HSN Code
- 29329900
- Synonyms
- Milk Thistle Extract
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Hepatoprotective agent, antioxidant
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.3 — Other hazards
- Other hazards
- None known
3.1 — Substance
- Name
- Silymarin
- CAS No.
- 65666-07-1
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- Wash with soap and water. If irritation occurs, seek medical attention.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. If irritation persists, seek medical attention.
- First-aid measures after ingestion
- Rinse mouth. Do not induce vomiting. Seek medical attention if symptoms occur.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- May cause mild irritation to skin and eyes.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- No special hazards identified.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Contain spill and collect using appropriate methods. Dispose of in accordance with local regulations.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Use appropriate personal protective equipment. Sweep up and place in a suitable container for disposal.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Avoid contact with skin and eyes. Use appropriate personal protective equipment.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Store in a cool, dry place, away from direct sunlight and moisture.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Not required under normal conditions of use.
9.1 — Information on basic physical and chemical properties
- Physical state
- Solid
- Colour
- Pale yellow to tan
- Odour
- Characteristic
- Odour threshold
- Not applicable
- pH value
- Not applicable
- Relative evaporation rate (butylacetate=1)
- Not applicable
- Melting point
- Not applicable
- Freezing point
- Not applicable
- Boiling point
- Not applicable
- Flash point
- Not applicable
- Auto-ignition temperature
- Not applicable
- Decomposition temperature
- Not applicable
- Flammability (solid, gas)
- Not flammable
- Vapour pressure
- Not applicable
- Relative vapour density at 20°C
- Not applicable
- Density
- Approx. 1.2 g/cm³
- Solubility
- Slightly soluble in water, soluble in alcohol
- Log Pow
- Not applicable
- Viscosity, kinematic
- Not applicable
- Viscosity, dynamic
- Not applicable
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- Not applicable
10.1 — Reactivity
- Reactivity
- Stable under normal conditions.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizing agents.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- No data available; generally regarded as safe when used appropriately.
- Skin corrosion/irritation
- May cause mild irritation.
- Serious eye damage/irritation
- May cause mild irritation.
- Respiratory or skin sensitisation
- Not expected to be a sensitizer.
- Germ cell mutagenicity
- Not classified
- Carcinogenicity
- Not classified
- Specific target organ toxicity (single exposure)
- Not classified as a specific target organ toxicant.
- Specific target organ toxicity (repeated exposure)
- Not classified
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- Not applicable
- UN-No. (IMDG)
- Not applicable
- UN-No. (IATA)
- Not applicable
- UN-No. (ADN)
- Not applicable
- UN-No. (RID)
- Not applicable
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Not classified as dangerous goods
- Proper Shipping Name (IMDG)
- Not classified as dangerous goods
- Proper Shipping Name (IATA)
- Not classified as dangerous goods
- Proper Shipping Name (ADN)
- Not classified as dangerous goods
- Proper Shipping Name (RID)
- Not classified as dangerous goods
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- Not applicable
14.4 — Packing group
- Packing group (ADR)
- Not applicable
- Packing group (IMDG)
- Not applicable
- Packing group (IATA)
- Not applicable
- Packing group (ADN)
- Not applicable
- Packing group (RID)
- Not applicable
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Silymarin is widely used in the pharmaceutical and nutraceutical industries, primarily as a reference standard in research related to hepatoprotection and antioxidant activity. It is commonly included in dietary supplements aimed at supporting liver health, detoxification, and overall wellness. Additionally, silymarin is studied for its potential benefits in managing liver diseases such as hepatitis and cirrhosis. Its antioxidant properties also make it a candidate for use in cosmetic formulations aimed at skin protection and anti-aging.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL2502A
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 482.44 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay (Purity) | ≥ 70% | 72% |
| Moisture Content | ≤ 5% | 3.2% |
| Residue on Ignition | ≤ 1% | 0.5% |
| Related Substances | None detected | None detected |
| Solubility | Slightly soluble in water, soluble in alcohol | Slightly soluble in water, soluble in ethanol |
The above product is expected to comply with Standard grade grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| Standard grade | ≥ 70% | Not applicable | ≤ 5% | ≤ 1% | None detected | Slightly soluble in water, soluble in alcohol |
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