Sulfadoxine
- CAS Number
- 2447-57-6
- HSN Code
- 29350090
- Molecular Formula
- C12H14N4O4S
- Catalogue Number
- AL1483D
- Purity
- ≥ 95%
- Molecular Weight
- 310.33 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Sulfadoxine (extra pure) is a long-acting sulfonamide antibiotic that has been historically utilized in combination antimalarial therapy. It is particularly notable for its role in enhancing the efficacy of other antimalarial agents, such as pyrimethamine, by inhibiting bacterial dihydropteroate synthase, which is crucial for folate synthesis. This compound is classified as a sulfonamide and is recognized for its extended half-life, allowing for less frequent dosing in therapeutic applications. The extra pure grade ensures high purity suitable for laboratory use and research applications.
Also known as N-(5,6-dimethyl-2-pyrimidinyl) sulfanilamide.
- Catalogue No.
- AL1483D
- CAS Number
- 2447-57-6
- Molecular Formula
- C12H14N4O4S
- Molecular Weight
- 310.33 g/mol
- HSN Code
- 29350090
- Grade
- Extra Pure
- Product Form
- Substance
Sulfadoxine appears as a white to pale yellow crystalline powder. It has a melting point of approximately 170-175 °C and is slightly soluble in water, with a solubility of about 0.1 g/100 mL at 25 °C. The compound has a density of approximately 1.4 g/cm³. It is stable under normal conditions but should be stored in a cool, dry place away from light to maintain its integrity. The compound has a pH value of around 5-7 in solution, indicating its mild acidity.
- Appearance
- White to pale yellow crystalline powder
- Shelf Life
- 2 years
- Packaging
- Available in 25 g and 100 g glass bottles
- Storage
- Store in a cool, dry place, away from light.
1.1 — Product identifier
- Chemical Name
- Sulfadoxine
- Catalogue No.
- AL1483D
- Product form
- Substance
- CAS Number
- 2447-57-6
- EC Number
- 219-052-0
- Grade
- Extra Pure
- EC Index Number
- Not applicable
- Chemical Formula
- C12H14N4O4S
- HSN Code
- 29350090
- Synonyms
- N-(5,6-dimethyl-2-pyrimidinyl) sulfanilamide
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Antibiotic, reference standard in pharmaceutical research
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.3 — Other hazards
- Other hazards
- None identified
3.1 — Substance
- Name
- Sulfadoxine
- CAS No.
- 2447-57-6
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- Wash with soap and water. If irritation occurs, seek medical attention.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. If irritation persists, seek medical attention.
- First-aid measures after ingestion
- Rinse mouth. Do not induce vomiting. Seek medical attention if symptoms occur.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- May cause allergic reactions in sensitive individuals, including skin rash or respiratory issues.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- No special hazards identified; use standard fire-fighting procedures.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Contain spill and collect using appropriate protective equipment. Dispose of in accordance with local regulations.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Use appropriate personal protective equipment. Sweep up and place in a suitable container for disposal.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Handle with gloves and avoid inhalation of dust. Ensure adequate ventilation in the work area.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Store in a tightly closed container in a cool, dry place.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respiratory protection if dust is generated.
9.1 — Information on basic physical and chemical properties
- Physical state
- Solid
- Colour
- White to pale yellow
- Odour
- Odourless
- Odour threshold
- Not applicable
- pH value
- 5-7
- Relative evaporation rate (butylacetate=1)
- Not applicable
- Melting point
- 170-175 °C
- Freezing point
- Not applicable
- Boiling point
- Not applicable
- Flash point
- Not applicable
- Auto-ignition temperature
- Not applicable
- Decomposition temperature
- Not applicable
- Flammability (solid, gas)
- Not flammable
- Vapour pressure
- Not applicable
- Relative vapour density at 20°C
- Not applicable
- Density
- 1.4 g/cm³
- Solubility
- Slightly soluble in water (0.1 g/100 mL at 25 °C)
- Log Pow
- Not applicable
- Viscosity, kinematic
- Not applicable
- Viscosity, dynamic
- Not applicable
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- Not applicable
10.1 — Reactivity
- Reactivity
- Stable under normal conditions; avoid strong oxidizing agents.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizing agents, strong acids.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- LD50 (oral, rat) > 2000 mg/kg; low acute toxicity.
- Skin corrosion/irritation
- May cause mild irritation in sensitive individuals.
- Serious eye damage/irritation
- May cause mild irritation; rinse thoroughly if contact occurs.
- Respiratory or skin sensitisation
- May cause allergic skin reactions in sensitized individuals.
- Germ cell mutagenicity
- Not classified
- Carcinogenicity
- Not classified
- Specific target organ toxicity (single exposure)
- Not classified as a specific target organ toxicant.
- Specific target organ toxicity (repeated exposure)
- Not classified
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- Not assigned
- UN-No. (IMDG)
- Not assigned
- UN-No. (IATA)
- Not assigned
- UN-No. (ADN)
- Not assigned
- UN-No. (RID)
- Not assigned
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Not classified as dangerous goods
- Proper Shipping Name (IMDG)
- Not classified as dangerous goods
- Proper Shipping Name (IATA)
- Not classified as dangerous goods
- Proper Shipping Name (ADN)
- Not classified as dangerous goods
- Proper Shipping Name (RID)
- Not classified as dangerous goods
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- Not applicable
14.4 — Packing group
- Packing group (ADR)
- Not applicable
- Packing group (IMDG)
- Not applicable
- Packing group (IATA)
- Not applicable
- Packing group (ADN)
- Not applicable
- Packing group (RID)
- Not applicable
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Sulfadoxine is primarily used as a reference standard in pharmaceutical quality control, particularly in the development and testing of antimalarial combination therapies. It is also employed in research settings to study the pharmacokinetics and pharmacodynamics of sulfonamide antibiotics. Additionally, sulfadoxine is utilized in veterinary medicine for the treatment of various infections in livestock. Its role in combination therapies has made it a critical component in the fight against malaria, especially in regions where resistance to other antimalarial drugs is prevalent.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL1483D
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 310.33 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay | ≥ 95% | 96.5% |
| Melting Point | 170-175 °C | 172 °C |
| Moisture Content | ≤ 0.5% | 0.3% |
| Residue on Ignition | ≤ 0.1% | 0.05% |
| Related Substances | None detected | None detected |
| Solubility | Slightly soluble in water | 0.1 g/100 mL at 25 °C |
The above product is expected to comply with Extra Pure grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| Extra Pure | ≥ 95% | 170-175 °C | ≤ 0.5% | ≤ 0.1% | None detected | Slightly soluble in water |
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