Tetra Methyl Ammonium Hydrogen Sulphate
- CAS Number
- 80526-82-5
- HSN Code
- 29239000
- Molecular Formula
- C4H13NO4S
- Catalogue Number
- AL2567C
- Purity
- 99%
- Molecular Weight
- 171.21 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Tetra Methyl Ammonium Hydrogen Sulphate (TMAS) is a quaternary ammonium salt that serves as a highly effective ion-pairing reagent in high-performance liquid chromatography (HPLC). With a purity of 99%, this HPLC-grade compound is specifically designed for ion-pair chromatography applications, making it essential for the separation of ionic and polar analytes. Its unique properties allow for enhanced resolution and sensitivity in chromatographic methods, particularly in reversed-phase systems. TMAS is recognized for its ability to improve the retention of acidic compounds, thus facilitating their analysis in complex mixtures.
Also known as TMAS, Tetramethylammonium hydrogen sulfate.
- Catalogue No.
- AL2567C
- CAS Number
- 80526-82-5
- Molecular Formula
- C4H13NO4S
- Molecular Weight
- 171.21 g/mol
- HSN Code
- 29239000
- Grade
- HPLC grade
- Product Form
- Substance
Tetra Methyl Ammonium Hydrogen Sulphate appears as a white crystalline powder. It is highly soluble in water, which is advantageous for its use in HPLC applications. The compound has a melting point of approximately 150 °C, and its density is around 1.2 g/cm³. The compound is stable under normal conditions and does not exhibit significant volatility, making it suitable for laboratory environments. Its hygroscopic nature requires proper storage to maintain its integrity and performance.
- Appearance
- White crystalline powder
- Shelf Life
- 2 years
- Packaging
- Available in 100 g and 500 g bottles
- Storage
- Store in a cool, dry place, away from direct sunlight.
1.1 — Product identifier
- Chemical Name
- Tetra Methyl Ammonium Hydrogen Sulphate
- Catalogue No.
- AL2567C
- Product form
- Substance
- CAS Number
- 80526-82-5
- EC Number
- Not applicable
- Grade
- HPLC grade
- EC Index Number
- Not applicable
- Chemical Formula
- C4H13NO4S
- HSN Code
- 29239000
- Synonyms
- TMAS, Tetramethylammonium hydrogen sulfate
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Ion-pairing reagent in HPLC
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.3 — Other hazards
- Other hazards
- None identified
3.1 — Substance
- Name
- Tetra Methyl Ammonium Hydrogen Sulphate
- CAS No.
- 80526-82-5
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- Wash with soap and water. If irritation occurs, seek medical attention.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. If irritation persists, seek medical attention.
- First-aid measures after ingestion
- Rinse mouth. Do not induce vomiting. Seek medical attention if symptoms occur.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- May cause mild irritation to skin, eyes, and respiratory tract.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- Non-flammable; however, thermal decomposition may produce toxic fumes.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Contain spill and absorb with inert material. Dispose of in accordance with local regulations.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Use appropriate personal protective equipment. Sweep up and place in a suitable container for disposal.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Avoid contact with skin and eyes. Use in a well-ventilated area.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Store in a cool, dry place, away from incompatible materials.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Not required under normal conditions; use in a well-ventilated area.
9.1 — Information on basic physical and chemical properties
- Physical state
- Solid
- Colour
- White
- Odour
- Odourless
- Odour threshold
- Not applicable
- pH value
- Not applicable
- Relative evaporation rate (butylacetate=1)
- Not applicable
- Melting point
- 150 °C
- Freezing point
- Not applicable
- Boiling point
- Not applicable
- Flash point
- Not applicable
- Auto-ignition temperature
- Not applicable
- Decomposition temperature
- Not applicable
- Flammability (solid, gas)
- Non-flammable
- Vapour pressure
- Not applicable
- Relative vapour density at 20°C
- Not applicable
- Density
- 1.2 g/cm³
- Solubility
- Soluble in water
- Log Pow
- Not applicable
- Viscosity, kinematic
- Not applicable
- Viscosity, dynamic
- Not applicable
- Explosive properties
- Not applicable
- Oxidising properties
- Not applicable
- Explosive limits
- Not applicable
10.1 — Reactivity
- Reactivity
- Stable under normal conditions; avoid strong oxidizing agents.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizing agents.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- Not classified as acutely toxic.
- Skin corrosion/irritation
- May cause mild irritation.
- Serious eye damage/irritation
- May cause mild irritation.
- Respiratory or skin sensitisation
- Not a sensitizer.
- Germ cell mutagenicity
- Not classified
- Carcinogenicity
- Not classified
- Specific target organ toxicity (single exposure)
- Not classified as a specific target organ toxicant.
- Specific target organ toxicity (repeated exposure)
- Not classified
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- Not assigned
- UN-No. (IMDG)
- Not assigned
- UN-No. (IATA)
- Not assigned
- UN-No. (ADN)
- Not assigned
- UN-No. (RID)
- Not assigned
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Not classified as dangerous goods
- Proper Shipping Name (IMDG)
- Not classified as dangerous goods
- Proper Shipping Name (IATA)
- Not classified as dangerous goods
- Proper Shipping Name (ADN)
- Not classified as dangerous goods
- Proper Shipping Name (RID)
- Not classified as dangerous goods
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- Not applicable
14.4 — Packing group
- Packing group (ADR)
- Not applicable
- Packing group (IMDG)
- Not applicable
- Packing group (IATA)
- Not applicable
- Packing group (ADN)
- Not applicable
- Packing group (RID)
- Not applicable
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Tetra Methyl Ammonium Hydrogen Sulphate is primarily used as an ion-pairing reagent in reversed-phase high-performance liquid chromatography (HPLC). It is particularly effective in the separation of acidic and ionic analytes, which are often challenging to analyze due to their polar nature. This compound is widely utilized in pharmaceutical analysis, environmental testing, and biochemical research, where precise separation and quantification of compounds are critical. Additionally, TMAS can be employed in the analysis of complex biological samples, enhancing the detection of low-concentration analytes.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL2567C
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 171.21 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay | 99% min | 99.5% |
| Moisture Content | <1% | 0.5% |
| Residue on Ignition | <0.1% | 0.05% |
| Related Substances | None detected | None detected |
The above product is expected to comply with HPLC grade grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| HPLC grade | 99% | 150 °C | <1% | <0.1% | None detected | Soluble in water |
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