Tetrahydrofuran
- CAS Number
- 109-99-9
- HSN Code
- 29321100
- Molecular Formula
- C4H8O
- Catalogue Number
- AL01499
- Purity
- 99%
- Molecular Weight
- 72.11 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Tetrahydrofuran (extra pure, stabilized with 0.1% quinol) is one of the most widely used polar aprotic ether solvents in organic synthesis. It is a colorless, water-miscible liquid that serves as an excellent solvent for a variety of organic compounds, including polymers, resins, and pharmaceuticals. Its unique properties allow it to dissolve both polar and nonpolar substances, making it invaluable in many chemical processes. Tetrahydrofuran is particularly notable for its ability to act as a solvent in Grignard reactions and other organometallic chemistry applications, where it facilitates the formation of reactive intermediates.
Also known as THF, 1,4-Butyrolactone.
- Catalogue No.
- AL01499
- CAS Number
- 109-99-9
- Molecular Formula
- C4H8O
- Molecular Weight
- 72.11 g/mol
- HSN Code
- 29321100
- Grade
- Extra Pure
- Product Form
- Substance
Tetrahydrofuran is a colorless liquid with a characteristic ether-like odor. It has a density of 0.889 g/mL at 20°C and a boiling point of approximately 66°C. The melting point is around -108°C, indicating its liquid state at room temperature. Tetrahydrofuran is highly soluble in water, as well as in many organic solvents, which enhances its utility in various chemical reactions. The vapor pressure is about 160 mmHg at 20°C, and it has a flash point of -14°C, highlighting its flammability.
- Appearance
- Colorless liquid
- Shelf Life
- 12 months
- Packaging
- Available in 1L, 5L, and 25L containers
- Storage
- Store in a cool, dry place away from heat and ignition sources.
1.1 — Product identifier
- Chemical Name
- Tetrahydrofuran
- Catalogue No.
- AL01499
- Product form
- Substance
- CAS Number
- 109-99-9
- EC Number
- 203-726-8
- Grade
- Extra Pure
- EC Index Number
- 607-195-00-7
- Chemical Formula
- C4H8O
- HSN Code
- 29321100
- Synonyms
- THF, 1,4-Butyrolactone
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Solvent in organic synthesis and chemical reactions
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.3 — Other hazards
- Other hazards
- Forms explosive peroxides upon prolonged storage; may cause skin and eye irritation.
3.1 — Substance
- Name
- Tetrahydrofuran
- CAS No.
- 109-99-9
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- Wash with soap and water. If irritation occurs, seek medical attention.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. If irritation persists, seek medical attention.
- First-aid measures after ingestion
- Do not induce vomiting. Rinse mouth and seek medical attention immediately.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Headache, dizziness, nausea, irritation of the skin and eyes.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- Highly flammable; may form explosive mixtures with air.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Evacuate area and eliminate all ignition sources. Ventilate area.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Contain spill with inert material and transfer to a suitable container for disposal.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Use in a well-ventilated area. Avoid contact with skin and eyes. Keep away from heat and ignition sources.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Store in tightly closed containers in a cool, dry place away from incompatible materials.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respiratory protection if ventilation is inadequate.
9.1 — Information on basic physical and chemical properties
- Physical state
- Liquid
- Colour
- Colorless
- Odour
- Characteristic ether-like
- Odour threshold
- Not specified
- pH value
- Not applicable
- Relative evaporation rate (butylacetate=1)
- Not specified
- Melting point
- -108 °C
- Freezing point
- Not specified
- Boiling point
- 66 °C
- Flash point
- -14 °C
- Auto-ignition temperature
- Not specified
- Decomposition temperature
- Not specified
- Flammability (solid, gas)
- Highly flammable
- Vapour pressure
- 160 mmHg at 20°C
- Relative vapour density at 20°C
- Not specified
- Density
- 0.889 g/mL
- Solubility
- Miscible with water and many organic solvents
- Log Pow
- Not specified
- Viscosity, kinematic
- Not specified
- Viscosity, dynamic
- Not specified
- Explosive properties
- Forms explosive peroxides upon prolonged storage
- Oxidising properties
- Not specified
- Explosive limits
- Not specified
10.1 — Reactivity
- Reactivity
- Stable under normal conditions; may react violently with strong oxidizers.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizing agents, strong acids, and bases.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- Oral LD50 (rat) 1,500 mg/kg; inhalation LC50 (rat) 2000 ppm/4h.
- Skin corrosion/irritation
- Causes skin irritation.
- Serious eye damage/irritation
- Causes serious eye irritation.
- Respiratory or skin sensitisation
- Not a skin sensitizer.
- Germ cell mutagenicity
- Not classified
- Carcinogenicity
- Not classified
- Specific target organ toxicity (single exposure)
- May cause drowsiness or dizziness.
- Specific target organ toxicity (repeated exposure)
- Not classified
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- UN 2056
- UN-No. (IMDG)
- UN 2056
- UN-No. (IATA)
- UN 2056
- UN-No. (ADN)
- UN 2056
- UN-No. (RID)
- UN 2056
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Tetrahydrofuran
- Proper Shipping Name (IMDG)
- Tetrahydrofuran
- Proper Shipping Name (IATA)
- Tetrahydrofuran
- Proper Shipping Name (ADN)
- Tetrahydrofuran
- Proper Shipping Name (RID)
- Tetrahydrofuran
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 3
14.4 — Packing group
- Packing group (ADR)
- II
- Packing group (IMDG)
- II
- Packing group (IATA)
- II
- Packing group (ADN)
- II
- Packing group (RID)
- II
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Tetrahydrofuran is widely used as a solvent in various chemical reactions, particularly in Grignard reactions and organometallic chemistry. It is also employed in the production of polymers, such as polytetrahydrofuran, which is used in the manufacture of spandex fibers. Additionally, THF serves as a solvent for coatings, adhesives, and inks, making it essential in the paint and coatings industry. Its ability to dissolve a wide range of substances makes it a valuable tool in laboratories for organic synthesis and research.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL01499
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 72.11 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay | 99% min | 99.5% |
| Density | 0.889 g/mL | 0.889 g/mL |
| Boiling Point | 66 °C | 66.2 °C |
| Water Content | <0.1% | 0.05% |
| Residue on Ignition | <0.01% | 0.005% |
| Related Substances | None detected | None detected |
The above product is expected to comply with Extra Pure grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| Extra Pure | 99% | -108 °C / 66 °C | <0.1% | <0.01% | None detected | Miscible with water |
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