Tetrahydrofuran
- CAS Number
- 109-99-9
- HSN Code
- 29321100
- Molecular Formula
- C4H8O
- Catalogue Number
- AL02566
- Purity
- 99.8%
- Molecular Weight
- 72.11 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Tetrahydrofuran (THF) is a colorless, water-miscible organic liquid with a distinctive ether-like odor. It is classified as a cyclic ether and is notable for its low UV-absorbing impurities, making it particularly suitable for high-performance liquid chromatography (HPLC) and spectroscopy applications. With a purity of 99.8%, this grade of THF is ideal for sensitive analytical techniques where background interference must be minimized. Its molecular weight is 72.11 g/mol, and it is widely used in various chemical processes and as a solvent in laboratories.
Also known as THF, 1,4-Butyrolactone.
- Catalogue No.
- AL02566
- CAS Number
- 109-99-9
- Molecular Formula
- C4H8O
- Molecular Weight
- 72.11 g/mol
- HSN Code
- 29321100
- Grade
- HPLC & Spectroscopy
- Product Form
- Substance
Tetrahydrofuran is a colorless liquid with a density of 0.889 g/mL at 20°C. It has a boiling point of 66°C and a melting point of -108°C. The liquid has a low UV background, making it suitable for UV-sensitive applications. THF is miscible with water and many organic solvents, which enhances its utility in various chemical reactions and analytical procedures. Its flash point is approximately -14°C, indicating its highly flammable nature.
- Appearance
- Colorless liquid
- Shelf Life
- 12 months
- Packaging
- Available in 1L and 5L glass bottles
- Storage
- Store in a cool, dry place away from heat and ignition sources.
1.1 — Product identifier
- Chemical Name
- Tetrahydrofuran
- Catalogue No.
- AL02566
- Product form
- Substance
- CAS Number
- 109-99-9
- EC Number
- 203-726-8
- Grade
- HPLC & Spectroscopy
- EC Index Number
- 607-195-00-7
- Chemical Formula
- C4H8O
- HSN Code
- 29321100
- Synonyms
- THF, 1,4-Butyrolactone
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Solvent for chromatography and spectroscopy
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.3 — Other hazards
- Other hazards
- Forms explosive peroxides upon prolonged exposure to air and light.
3.1 — Substance
- Name
- Tetrahydrofuran
- CAS No.
- 109-99-9
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If breathing is difficult, give oxygen. Seek medical attention if symptoms persist.
- First-aid measures after skin contact
- Wash with soap and water. Remove contaminated clothing. Seek medical attention if irritation develops.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Seek medical attention if irritation persists.
- First-aid measures after ingestion
- Do not induce vomiting. Rinse mouth and seek medical attention immediately.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Headache, dizziness, nausea, respiratory irritation, skin irritation.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- Highly flammable. Vapors may form explosive mixtures with air.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Evacuate area. Remove all sources of ignition. Ventilate area.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Contain spill with inert material and transfer to a suitable container for disposal. Avoid runoff into waterways.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Use in a well-ventilated area. Avoid contact with skin and eyes. Keep away from heat and ignition sources.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Store in tightly closed containers in a cool, dry, well-ventilated area away from incompatible materials.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respiratory protection if ventilation is inadequate.
9.1 — Information on basic physical and chemical properties
- Physical state
- Liquid
- Colour
- Colorless
- Odour
- Ether-like
- Odour threshold
- Not specified
- pH value
- Not applicable
- Relative evaporation rate (butylacetate=1)
- >1
- Melting point
- -108°C
- Freezing point
- Not specified
- Boiling point
- 66°C
- Flash point
- -14°C
- Auto-ignition temperature
- 320°C
- Decomposition temperature
- Not specified
- Flammability (solid, gas)
- Highly flammable liquid
- Vapour pressure
- 160 mmHg at 20°C
- Relative vapour density at 20°C
- 1.6
- Density
- 0.889 g/mL
- Solubility
- Miscible with water and organic solvents
- Log Pow
- -0.24
- Viscosity, kinematic
- 0.45 cSt at 20°C
- Viscosity, dynamic
- Not specified
- Explosive properties
- Forms explosive peroxides
- Oxidising properties
- Not oxidizing
- Explosive limits
- 1.8 - 11.8% (v/v) in air
10.1 — Reactivity
- Reactivity
- Reacts violently with strong oxidizers and can form peroxides upon exposure to air.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizing agents, strong acids, and bases.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- Oral LD50 (rat) 1,500 mg/kg; Dermal LD50 (rabbit) 1,000 mg/kg.
- Skin corrosion/irritation
- Causes skin irritation.
- Serious eye damage/irritation
- Causes serious eye irritation.
- Respiratory or skin sensitisation
- Not a skin sensitizer.
- Germ cell mutagenicity
- Not classified
- Carcinogenicity
- Not classified
- Specific target organ toxicity (single exposure)
- May cause respiratory irritation.
- Specific target organ toxicity (repeated exposure)
- Not classified
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- 2056
- UN-No. (IMDG)
- 2056
- UN-No. (IATA)
- 2056
- UN-No. (ADN)
- 2056
- UN-No. (RID)
- 2056
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Tetrahydrofuran
- Proper Shipping Name (IMDG)
- Tetrahydrofuran
- Proper Shipping Name (IATA)
- Tetrahydrofuran
- Proper Shipping Name (ADN)
- Tetrahydrofuran
- Proper Shipping Name (RID)
- Tetrahydrofuran
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 3
14.4 — Packing group
- Packing group (ADR)
- II
- Packing group (IMDG)
- II
- Packing group (IATA)
- II
- Packing group (ADN)
- II
- Packing group (RID)
- II
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Tetrahydrofuran is primarily used as a solvent in chromatographic techniques, particularly as a mobile-phase solvent in gel permeation chromatography (GPC) and size exclusion chromatography (SEC) for polymer molecular-weight analysis. It is also utilized in the synthesis of polymers, pharmaceuticals, and as a solvent for various chemical reactions. Additionally, THF serves as a reagent in the production of tetrahydrofuran-based polymers and is used in the formulation of coatings, adhesives, and sealants in the chemical industry.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL02566
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 72.11 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay | 99.8% min | 99.85% |
| Water Content | <0.1% | 0.05% |
| Residue on Ignition | <0.01% | 0.005% |
| Related Substances | <0.1% | 0.03% |
| Appearance | Colorless liquid | Colorless liquid |
The above product is expected to comply with HPLC & Spectroscopy grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| HPLC & Spectroscopy | 99.8% | -108°C / 66°C | <0.1% | <0.01% | <0.1% | Miscible with water |
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