Tetrakis(triphenylphosphine)palladium(0)
- CAS Number
- 14221-01-3
- HSN Code
- 28439019
- Molecular Formula
- C72H60P4Pd
- Catalogue Number
- AL2566C
- Purity
- ≥ 99%
- Molecular Weight
- 1155.56 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Tetrakis(triphenylphosphine)palladium(0) is a highly effective and widely utilized palladium(0) catalyst known for its role in facilitating cross-coupling reactions in organic synthesis. This compound is particularly valued for its versatility and efficiency in various coupling reactions, including Suzuki, Negishi, Stille, and Sonogashira reactions. With a purity of 99%, it is suitable for high-precision synthesis applications. Its molecular structure, featuring four triphenylphosphine ligands coordinated to a palladium center, contributes to its unique catalytic properties, making it a staple in both academic and industrial laboratories.
Also known as Tetrakis(triphenylphosphine)palladium, Pd(PPh3)4.
- Catalogue No.
- AL2566C
- CAS Number
- 14221-01-3
- Molecular Formula
- C72H60P4Pd
- Molecular Weight
- 1155.56 g/mol
- HSN Code
- 28439019
- Grade
- 99%
- Product Form
- Substance
Tetrakis(triphenylphosphine)palladium(0) appears as a bright yellow crystalline solid, which is indicative of its palladium content. It is air-sensitive, necessitating careful handling under inert conditions to prevent degradation. The compound is soluble in a variety of organic solvents, which enhances its utility in organic synthesis. The melting point of this compound is approximately 180-185 °C, and it has a density of around 1.25 g/cm³. Its solubility in common organic solvents such as dichloromethane and toluene makes it accessible for various synthetic applications.
- Appearance
- Bright yellow crystalline solid
- Shelf Life
- -
- Packaging
- -
- Storage
- Store at 2-8°C under inert atmosphere to prevent degradation.
1.1 — Product identifier
- Chemical Name
- Tetrakis(triphenylphosphine)palladium(0)
- Catalogue No.
- AL2566C
- Product form
- Substance
- CAS Number
- 14221-01-3
- EC Number
- Not specified
- Grade
- 99%
- EC Index Number
- Not specified
- Chemical Formula
- C72H60P4Pd
- HSN Code
- 28439019
- Synonyms
- Tetrakis(triphenylphosphine)palladium, Pd(PPh3)4
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Catalyst in organic synthesis
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.3 — Other hazards
- Other hazards
- Air-sensitive, light-sensitive
3.1 — Substance
- Name
- Tetrakis(triphenylphosphine)palladium(0)
- CAS No.
- 14221-01-3
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- Wash with soap and water. If irritation occurs, seek medical attention.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. If irritation persists, seek medical attention.
- First-aid measures after ingestion
- Do not induce vomiting. Rinse mouth and seek medical attention.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- May cause irritation to skin, eyes, and respiratory tract.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- May emit toxic fumes under fire conditions.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Evacuate area and ventilate. Use appropriate protective equipment.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Contain spill and collect using inert material. Dispose of in accordance with local regulations.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Handle under inert atmosphere. Use appropriate personal protective equipment (PPE).
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Store in a cool, dry place under inert atmosphere.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respiratory protection if airborne concentrations exceed recommended limits.
9.1 — Information on basic physical and chemical properties
- Physical state
- Solid
- Colour
- Bright yellow
- Odour
- Odourless
- Odour threshold
- Not specified
- pH value
- Not applicable
- Relative evaporation rate (butylacetate=1)
- Not applicable
- Melting point
- 180-185 °C
- Freezing point
- Not applicable
- Boiling point
- Not applicable
- Flash point
- Not applicable
- Auto-ignition temperature
- Not applicable
- Decomposition temperature
- Not specified
- Flammability (solid, gas)
- Not flammable under normal conditions
- Vapour pressure
- Not applicable
- Relative vapour density at 20°C
- Not applicable
- Density
- ~1.25 g/cm³
- Solubility
- Soluble in organic solvents such as dichloromethane and toluene
- Log Pow
- Not specified
- Viscosity, kinematic
- Not applicable
- Viscosity, dynamic
- Not applicable
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- Not applicable
10.1 — Reactivity
- Reactivity
- Stable under recommended storage conditions; reacts with strong oxidizing agents.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizers, moisture.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- Not classified as acutely toxic; however, may cause irritation.
- Skin corrosion/irritation
- May cause skin irritation.
- Serious eye damage/irritation
- May cause eye irritation.
- Respiratory or skin sensitisation
- Not classified as a sensitizer.
- Germ cell mutagenicity
- Not classified
- Carcinogenicity
- Not classified
- Specific target organ toxicity (single exposure)
- Not classified as a specific target organ toxicant.
- Specific target organ toxicity (repeated exposure)
- Not classified
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- Not assigned
- UN-No. (IMDG)
- Not assigned
- UN-No. (IATA)
- Not assigned
- UN-No. (ADN)
- Not assigned
- UN-No. (RID)
- Not assigned
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Not classified as dangerous goods
- Proper Shipping Name (IMDG)
- Not classified as dangerous goods
- Proper Shipping Name (IATA)
- Not classified as dangerous goods
- Proper Shipping Name (ADN)
- Not classified as dangerous goods
- Proper Shipping Name (RID)
- Not classified as dangerous goods
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- Not applicable
14.4 — Packing group
- Packing group (ADR)
- Not applicable
- Packing group (IMDG)
- Not applicable
- Packing group (IATA)
- Not applicable
- Packing group (ADN)
- Not applicable
- Packing group (RID)
- Not applicable
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
This palladium(0) complex is predominantly used as a catalyst in cross-coupling reactions, which are essential in the formation of carbon-carbon bonds in organic chemistry. It plays a crucial role in the Suzuki reaction, where it facilitates the coupling of aryl halides with boronic acids, and in the Negishi reaction, which involves the coupling of organozinc reagents with organic halides. Additionally, it is employed in the Stille reaction for the coupling of organotin compounds and in the Sonogashira reaction for the formation of alkynes. Its applications extend to the pharmaceutical industry, materials science, and the development of fine chemicals, making it a vital component in modern synthetic methodologies.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL2566C
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 1155.56 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay Purity | ≥ 99% | 99.5% |
| Melting Point | 180-185 °C | 182 °C |
| Moisture Content | ≤ 0.5% | 0.3% |
| Residue on Ignition | ≤ 0.1% | 0.05% |
| Related Substances | None detected | None detected |
| Solubility | Soluble in organic solvents | Soluble in dichloromethane and toluene. |
The above product is expected to comply with 99% grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| 99% | ≥ 99% | 180-185 °C | ≤ 0.5% | ≤ 0.1% | None detected | Soluble in organic solvents |
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