Theophylline Anhydrous
- CAS Number
- 58-55-9
- HSN Code
- 29395900
- Molecular Formula
- C7H8N4O2
- Catalogue Number
- AL2567J
- Purity
- 99%
- Molecular Weight
- 180.17 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Theophylline anhydrous (extra pure) is a xanthine-class drug that is primarily utilized as a bronchodilator in the treatment of respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). This compound is notable for its ability to relax bronchial smooth muscle, thereby improving airflow and alleviating symptoms associated with bronchospasm. Theophylline is also used in various research applications, particularly in pharmacology and toxicology, due to its well-characterized pharmacokinetics and pharmacodynamics. As an extra pure grade, it meets stringent quality standards suitable for laboratory use and research purposes.
Also known as 1,3-Dimethylxanthine.
- Catalogue No.
- AL2567J
- CAS Number
- 58-55-9
- Molecular Formula
- C7H8N4O2
- Molecular Weight
- 180.17 g/mol
- HSN Code
- 29395900
- Grade
- Extra Pure
- Product Form
- Substance
Theophylline anhydrous appears as a white crystalline powder, which is typically odorless. It has a melting point of approximately 272 °C and is slightly soluble in water, with a solubility of about 0.67 g/L at 25 °C. The compound has a density of 1.2 g/cm³ and a boiling point of 400 °C. Theophylline exhibits a pH value of around 7 in aqueous solutions, indicating its neutral nature. It is stable under normal conditions but should be stored in a cool, dry place to maintain its integrity.
- Appearance
- White crystalline powder
- Shelf Life
- 2 years
- Packaging
- Available in 100 g and 500 g glass bottles
- Storage
- Store in a cool, dry place, away from light.
1.1 — Product identifier
- Chemical Name
- Theophylline Anhydrous
- Catalogue No.
- AL2567J
- Product form
- Substance
- CAS Number
- 58-55-9
- EC Number
- 200-400-3
- Grade
- Extra Pure
- EC Index Number
- Not applicable
- Chemical Formula
- C7H8N4O2
- HSN Code
- 29395900
- Synonyms
- 1,3-Dimethylxanthine
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Pharmaceutical reference standard, bronchodilator
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.3 — Other hazards
- Other hazards
- Pharmacologically active compound; handle with care.
3.1 — Substance
- Name
- Theophylline Anhydrous
- CAS No.
- 58-55-9
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- Wash with soap and water. If irritation occurs, seek medical attention.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. If irritation persists, seek medical attention.
- First-aid measures after ingestion
- Rinse mouth. Do not induce vomiting. Seek medical attention if symptoms occur.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Nausea, vomiting, headache, insomnia, and increased heart rate may occur in case of overdose.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- Combustible material; may emit toxic fumes when burned.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Evacuate area and ventilate. Wear appropriate protective equipment.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Collect spillage with suitable absorbent material and dispose of in accordance with local regulations.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Avoid contact with skin and eyes. Use personal protective equipment as required.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Store in a tightly closed container in a cool, dry place.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respiratory protection if dust is generated.
9.1 — Information on basic physical and chemical properties
- Physical state
- Solid
- Colour
- White
- Odour
- Odourless
- Odour threshold
- Not applicable
- pH value
- 7
- Relative evaporation rate (butylacetate=1)
- Not applicable
- Melting point
- 272 °C
- Freezing point
- Not applicable
- Boiling point
- 400 °C
- Flash point
- Not applicable
- Auto-ignition temperature
- Not applicable
- Decomposition temperature
- Not applicable
- Flammability (solid, gas)
- Not flammable
- Vapour pressure
- Not applicable
- Relative vapour density at 20°C
- Not applicable
- Density
- 1.2 g/cm³
- Solubility
- 0.67 g/L in water at 25 °C
- Log Pow
- -0.07
- Viscosity, kinematic
- Not applicable
- Viscosity, dynamic
- Not applicable
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- Not applicable
10.1 — Reactivity
- Reactivity
- Stable under normal conditions; incompatible with strong oxidizing agents.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizing agents, strong acids.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- LD50 (oral, rat) = 250 mg/kg.
- Skin corrosion/irritation
- May cause mild irritation.
- Serious eye damage/irritation
- May cause mild irritation.
- Respiratory or skin sensitisation
- Not a sensitizer.
- Germ cell mutagenicity
- Not classified
- Carcinogenicity
- Not classified
- Specific target organ toxicity (single exposure)
- May cause respiratory irritation with excessive exposure.
- Specific target organ toxicity (repeated exposure)
- Not classified
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- UN 2811
- UN-No. (IMDG)
- UN 2811
- UN-No. (IATA)
- UN 2811
- UN-No. (ADN)
- UN 2811
- UN-No. (RID)
- UN 2811
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Toxic solid, organic, N.O.S.
- Proper Shipping Name (IMDG)
- Toxic solid, organic, N.O.S.
- Proper Shipping Name (IATA)
- Toxic solid, organic, N.O.S.
- Proper Shipping Name (ADN)
- Toxic solid, organic, N.O.S.
- Proper Shipping Name (RID)
- Toxic solid, organic, N.O.S.
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 6.1
14.4 — Packing group
- Packing group (ADR)
- III
- Packing group (IMDG)
- III
- Packing group (IATA)
- III
- Packing group (ADN)
- III
- Packing group (RID)
- III
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Theophylline anhydrous is extensively used in the pharmaceutical industry as a reference standard for quality control in the development and testing of bronchodilator medications. It serves as a critical component in research studies aimed at understanding the pharmacological effects of xanthine derivatives. Additionally, it is utilized in the formulation of various therapeutic agents for respiratory diseases, contributing to the management of asthma and COPD. The compound is also employed in laboratory settings for analytical purposes, including high-performance liquid chromatography (HPLC) and other analytical techniques.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL2567J
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 180.17 g/mol
| Test | Standard | Observed |
|---|---|---|
| Description | White crystalline powder | White crystalline powder |
| Assay | Min. 99.0% | 99.22% |
| Melting point | 271 - 273°C | 273°C |
| Loss on Drying | <0.5% | 0.3% |
The above product complies with EP grade
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| Extra Pure | 99% | 272 °C | <0.5% | <0.1% | None detected | 0.67 g/L in water at 25 °C |
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