Tizanidine Hydrochloride
- CAS Number
- 64461-82-1
- HSN Code
- 29349900
- Molecular Formula
- C9H9Cl2N5S
- Catalogue Number
- AL1522A
- Purity
- 98% min
- Molecular Weight
- 290.17 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Tizanidine hydrochloride is a muscle relaxant that is primarily used to manage muscle spasticity resulting from conditions such as multiple sclerosis or spinal cord injury. It acts as an alpha-2 adrenergic agonist, which helps to reduce muscle tone and improve mobility. This compound is notable for its rapid onset of action and relatively short half-life, making it a preferred choice in acute settings. Tizanidine hydrochloride is classified as a pharmaceutical compound and is often utilized in clinical and research settings for its therapeutic properties.
Also known as Tizanidine HCl.
- Catalogue No.
- AL1522A
- CAS Number
- 64461-82-1
- Molecular Formula
- C9H9Cl2N5S
- Molecular Weight
- 290.17 g/mol
- HSN Code
- 29349900
- Grade
- 98%
- Product Form
- Substance
Tizanidine hydrochloride appears as a white to pale yellow crystalline powder. It has a melting point of approximately 175-180 °C and is slightly soluble in water, with a solubility of about 1.5 mg/mL at 25 °C. The compound has a density of approximately 1.3 g/cm³. It is stable under normal conditions but should be stored in a cool, dry place away from light to maintain its integrity. The compound has a pH range of 4.5 to 6.5 when dissolved in water, indicating its slightly acidic nature.
- Appearance
- White to pale yellow crystalline powder
- Shelf Life
- 2 years
- Packaging
- Available in 100 g and 500 g containers
- Storage
- Store in a cool, dry place, away from light and moisture.
1.1 — Product identifier
- Chemical Name
- Tizanidine Hydrochloride
- Catalogue No.
- AL1522A
- Product form
- Substance
- CAS Number
- 64461-82-1
- EC Number
- None
- Grade
- 98%
- EC Index Number
- None
- Chemical Formula
- C9H9Cl2N5S
- HSN Code
- 29349900
- Synonyms
- Tizanidine HCl
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Muscle relaxant, pharmaceutical reference standard
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.3 — Other hazards
- Other hazards
- None identified
3.1 — Substance
- Name
- Tizanidine Hydrochloride
- CAS No.
- 64461-82-1
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- Wash with soap and water. If irritation occurs, seek medical attention.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. If irritation persists, seek medical attention.
- First-aid measures after ingestion
- Do not induce vomiting. Rinse mouth and seek medical attention immediately.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Drowsiness, dry mouth, dizziness, hypotension.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- May emit toxic fumes under fire conditions.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Contain spill and collect using appropriate protective equipment. Dispose of in accordance with local regulations.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Use appropriate personal protective equipment. Sweep up and place in a suitable container for disposal.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Handle with gloves and avoid contact with skin and eyes. Use in a well-ventilated area.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Store in a cool, dry place, away from light and moisture.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respiratory protection if dust is generated.
9.1 — Information on basic physical and chemical properties
- Physical state
- Solid
- Colour
- White to pale yellow
- Odour
- Odourless
- Odour threshold
- Not applicable
- pH value
- 4.5 - 6.5
- Relative evaporation rate (butylacetate=1)
- Not applicable
- Melting point
- 175-180 °C
- Freezing point
- Not applicable
- Boiling point
- Not applicable
- Flash point
- Not applicable
- Auto-ignition temperature
- Not applicable
- Decomposition temperature
- Not applicable
- Flammability (solid, gas)
- Not flammable
- Vapour pressure
- Not applicable
- Relative vapour density at 20°C
- Not applicable
- Density
- 1.3 g/cm³
- Solubility
- Slightly soluble in water (1.5 mg/mL at 25 °C)
- Log Pow
- Not applicable
- Viscosity, kinematic
- Not applicable
- Viscosity, dynamic
- Not applicable
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- Not applicable
10.1 — Reactivity
- Reactivity
- Stable under normal conditions.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizing agents.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- LD50 (oral, rat) = 1000 mg/kg (approximate)
- Skin corrosion/irritation
- May cause mild irritation.
- Serious eye damage/irritation
- May cause mild irritation.
- Respiratory or skin sensitisation
- Not a sensitizer.
- Germ cell mutagenicity
- Not classified
- Carcinogenicity
- Not classified
- Specific target organ toxicity (single exposure)
- Not classified as a specific target organ toxicant.
- Specific target organ toxicity (repeated exposure)
- Not classified
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- Not assigned
- UN-No. (IMDG)
- Not assigned
- UN-No. (IATA)
- Not assigned
- UN-No. (ADN)
- Not assigned
- UN-No. (RID)
- Not assigned
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Not regulated
- Proper Shipping Name (IMDG)
- Not regulated
- Proper Shipping Name (IATA)
- Not regulated
- Proper Shipping Name (ADN)
- Not regulated
- Proper Shipping Name (RID)
- Not regulated
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- Not applicable
14.4 — Packing group
- Packing group (ADR)
- Not applicable
- Packing group (IMDG)
- Not applicable
- Packing group (IATA)
- Not applicable
- Packing group (ADN)
- Not applicable
- Packing group (RID)
- Not applicable
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Tizanidine hydrochloride is primarily used in the pharmaceutical industry as a muscle relaxant for the treatment of spasticity. It is commonly prescribed for patients with neurological disorders, such as multiple sclerosis and spinal cord injuries, to alleviate muscle stiffness and improve mobility. Additionally, it serves as a reference standard in pharmaceutical quality control laboratories for the development and testing of muscle relaxant formulations. Its role in research extends to studies investigating the pharmacodynamics and pharmacokinetics of muscle relaxants, making it a valuable compound in both clinical and laboratory settings.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL1522A
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 290.17 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay | 98% min | 98.5% |
| Melting Point | 175-180 °C | 178 °C |
| Moisture Content | <1% | 0.5% |
| Residue on Ignition | <0.1% | 0.05% |
| Related Substances | None detected | None detected |
The above product is expected to comply with 98% grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| 98% | 98% min | 175-180 °C | <1% | <0.1% | None detected | Slightly soluble in water |
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