Topfer's Reagent Solution
- CAS Number
- -
- HSN Code
- 38229090
- Molecular Formula
- C13H15N3O
- Catalogue Number
- AL01536
- Purity
- N/A
- Molecular Weight
- 229.28 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Topfer's reagent solution is a classic clinical chemistry reagent primarily used for detecting free hydrochloric acid in gastric juice. This reagent is notable for its application in clinical settings, particularly in gastric acidity testing, where it serves as a reliable indicator of gastric acid levels. The solution is prepared with dimethylaminoazobenzene dissolved in alcohol, making it a ready-to-use formulation for laboratory analysis. Its distinctive yellow-orange color provides a visual cue for the presence of hydrochloric acid, facilitating quick assessments in clinical diagnostics.
Also known as Dimethylaminoazobenzene in alcohol.
- Catalogue No.
- AL01536
- CAS Number
- -
- Molecular Formula
- C13H15N3O
- Molecular Weight
- 229.28 g/mol
- HSN Code
- 38229090
- Grade
- Ready-to-use solution
- Product Form
- Mixture
Topfer's reagent solution appears as a yellow-orange liquid, indicative of its active components. The solution is flammable due to its methanol base, with a flash point of approximately 12 °C (53.6 °F). It has a density of about 0.9 g/cm³, which is typical for organic solvents. The solution is soluble in water, allowing for easy integration into various laboratory procedures. Its pH is typically around 7, making it neutral and suitable for use in biological samples.
- Appearance
- Yellow-orange liquid
- Shelf Life
- 12 months
- Packaging
- Available in 100 mL and 500 mL bottles
- Storage
- Store in a cool, dry place away from heat and ignition sources.
1.1 — Product identifier
- Chemical Name
- Topfer's Reagent Solution
- Catalogue No.
- AL01536
- Product form
- Mixture
- CAS Number
- Not applicable
- EC Number
- Not applicable
- Grade
- Ready-to-use solution
- EC Index Number
- Not applicable
- Chemical Formula
- C13H15N3O
- HSN Code
- 38229090
- Synonyms
- Dimethylaminoazobenzene in alcohol
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Clinical reagent for detecting free hydrochloric acid in gastric juice
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.3 — Other hazards
- Other hazards
- Flammable liquid and vapor; may cause respiratory irritation.
3.1 — Substance
- Name
- Topfer's Reagent Solution
- CAS No.
- Not applicable
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- Wash with soap and water. If irritation occurs, seek medical attention.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Seek medical attention if irritation persists.
- First-aid measures after ingestion
- Do not induce vomiting. Rinse mouth and seek medical attention immediately.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Headache, dizziness, nausea, and irritation of the respiratory tract.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- Flammable; vapors may form explosive mixtures with air.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Evacuate area and ventilate. Use appropriate protective equipment.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Contain spill with inert material and dispose of according to local regulations.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Avoid contact with skin and eyes. Use in a well-ventilated area.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Store in a cool, dry place away from heat sources and incompatible materials.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respiratory protection if ventilation is inadequate.
9.1 — Information on basic physical and chemical properties
- Physical state
- Liquid
- Colour
- Yellow-orange
- Odour
- Alcoholic
- Odour threshold
- Not applicable
- pH value
- 7
- Relative evaporation rate (butylacetate=1)
- Not specified
- Melting point
- Not applicable
- Freezing point
- Not applicable
- Boiling point
- Not specified
- Flash point
- 12 °C
- Auto-ignition temperature
- Not specified
- Decomposition temperature
- Not specified
- Flammability (solid, gas)
- Flammable liquid
- Vapour pressure
- Not specified
- Relative vapour density at 20°C
- Not specified
- Density
- 0.9 g/cm³
- Solubility
- Soluble in water
- Log Pow
- Not specified
- Viscosity, kinematic
- Not specified
- Viscosity, dynamic
- Not specified
- Explosive properties
- Not applicable
- Oxidising properties
- Not applicable
- Explosive limits
- Not specified
10.1 — Reactivity
- Reactivity
- Stable under normal conditions; avoid heat and ignition sources.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizing agents, strong acids, and bases.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- Toxic if inhaled or absorbed through skin; may cause respiratory irritation.
- Skin corrosion/irritation
- Causes skin irritation.
- Serious eye damage/irritation
- Causes serious eye irritation.
- Respiratory or skin sensitisation
- May cause allergic skin reaction.
- Germ cell mutagenicity
- Not classified
- Carcinogenicity
- Not classified
- Specific target organ toxicity (single exposure)
- May cause respiratory irritation.
- Specific target organ toxicity (repeated exposure)
- Not classified
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- UN 1230
- UN-No. (IMDG)
- UN 1230
- UN-No. (IATA)
- UN 1230
- UN-No. (ADN)
- UN 1230
- UN-No. (RID)
- UN 1230
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Flammable liquid, n.o.s. (contains methanol)
- Proper Shipping Name (IMDG)
- Flammable liquid, n.o.s. (contains methanol)
- Proper Shipping Name (IATA)
- Flammable liquid, n.o.s. (contains methanol)
- Proper Shipping Name (ADN)
- Flammable liquid, n.o.s. (contains methanol)
- Proper Shipping Name (RID)
- Flammable liquid, n.o.s. (contains methanol)
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 3
14.4 — Packing group
- Packing group (ADR)
- II
- Packing group (IMDG)
- II
- Packing group (IATA)
- II
- Packing group (ADN)
- II
- Packing group (RID)
- II
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Topfer's reagent solution is widely used in clinical laboratories for the detection of free hydrochloric acid in gastric juice, which is crucial for diagnosing various gastrointestinal disorders. It serves as a classical pH indicator, providing a colorimetric response that indicates the acidity of gastric contents. This reagent is particularly valuable in the assessment of gastric secretory function and is utilized in both diagnostic and research settings. Additionally, it may find applications in educational laboratories for teaching purposes related to acid-base chemistry and indicator behavior.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL01536
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 229.28 g/mol
| Test | Standard | Observed |
|---|---|---|
| Appearance | Yellow-orange liquid | Yellow-orange liquid |
| Density | 0.9 g/cm³ | 0.89 g/cm³ |
| Flash Point | < 12 °C | 10 °C |
| pH | 7 | 7.0 |
| Solubility | Soluble in water | Soluble in water |
The above product is expected to comply with Ready-to-use solution grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| Ready-to-use solution | N/A | N/A | N/A | N/A | N/A | Soluble in water |
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