Trifluoroacetic Acid
- CAS Number
- 76-05-1
- HSN Code
- 29159099
- Molecular Formula
- C2HF3O2
- Catalogue Number
- AL02580
- Purity
- ≥ 98%
- Molecular Weight
- 114.02 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Trifluoroacetic acid (extra pure, TFA) is one of the most widely used strong organic acids, essential in peptide synthesis and HPLC mobile phases. It is a colorless, fuming liquid that is highly corrosive and has a sharp, pungent odor. With a molecular weight of 114.02 g/mol and a purity of 98%, this reagent is critical in various chemical processes, particularly in the synthesis of peptides and proteins. Its unique properties make it an invaluable tool in analytical chemistry and biochemistry, where precision and purity are paramount.
Also known as TFA, Trifluoroacetic Acid.
- Catalogue No.
- AL02580
- CAS Number
- 76-05-1
- Molecular Formula
- C2HF3O2
- Molecular Weight
- 114.02 g/mol
- HSN Code
- 29159099
- Grade
- 98% Extra Pure
- Product Form
- Substance
Trifluoroacetic acid is a colorless fuming liquid with a density of 1.489 g/mL. It has a boiling point of approximately 72 °C and a melting point of -15 °C. The acid has a sharp, pungent odor and is highly soluble in water, making it effective in various aqueous applications. Its vapor pressure at 20 °C is about 20 mmHg, indicating its volatility. The acid is also known for its corrosive nature, which necessitates careful handling and storage.
- Appearance
- Colorless fuming liquid
- Shelf Life
- -
- Packaging
- -
- Storage
- Store in a cool, dry place, away from incompatible materials.
1.1 — Product identifier
- Chemical Name
- Trifluoroacetic Acid
- Catalogue No.
- AL02580
- Product form
- Substance
- CAS Number
- 76-05-1
- EC Number
- 218-200-0
- Grade
- 98% Extra Pure
- EC Index Number
- 607-198-00-6
- Chemical Formula
- C2HF3O2
- HSN Code
- 29159099
- Synonyms
- TFA, Trifluoroacetic Acid
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Used in peptide synthesis and HPLC mobile phases.
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.3 — Other hazards
- Other hazards
- Corrosive to metals; may cause severe skin burns and eye damage.
3.1 — Substance
- Name
- Trifluoroacetic Acid
- CAS No.
- 76-05-1
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Remove to fresh air. If breathing is difficult, give oxygen. Seek medical attention immediately.
- First-aid measures after skin contact
- Remove contaminated clothing. Rinse skin with plenty of water for at least 15 minutes. Seek medical attention.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Seek medical attention immediately.
- First-aid measures after ingestion
- Do not induce vomiting. Rinse mouth. Seek medical attention immediately.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Severe burns, respiratory distress, and irritation of the skin and eyes.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- May produce toxic fumes in a fire. Use water spray to cool containers exposed to fire.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Evacuate area. Wear appropriate protective equipment. Contain spill and absorb with inert material.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Neutralize with a weak base and absorb with inert material. Dispose of in accordance with local regulations.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Use in a fume hood with appropriate PPE including gloves and goggles. Avoid contact with skin and eyes.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Store in a cool, dry place, in a tightly closed container. Keep away from incompatible materials such as strong bases and oxidizers.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respiratory protection if ventilation is inadequate.
9.1 — Information on basic physical and chemical properties
- Physical state
- Liquid
- Colour
- Colorless
- Odour
- Sharp, pungent
- Odour threshold
- Not specified
- pH value
- Not specified
- Relative evaporation rate (butylacetate=1)
- Not specified
- Melting point
- -15 °C
- Freezing point
- Not specified
- Boiling point
- 72 °C
- Flash point
- Not applicable
- Auto-ignition temperature
- Not applicable
- Decomposition temperature
- Not specified
- Flammability (solid, gas)
- Not flammable
- Vapour pressure
- 20 mmHg at 20 °C
- Relative vapour density at 20°C
- Not specified
- Density
- 1.489 g/mL
- Solubility
- Miscible with water
- Log Pow
- Not specified
- Viscosity, kinematic
- Not specified
- Viscosity, dynamic
- Not specified
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- Not applicable
10.1 — Reactivity
- Reactivity
- Reacts violently with strong bases and oxidizing agents.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong bases, oxidizing agents, and metals.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- Toxic if inhaled, ingested, or absorbed through skin.
- Skin corrosion/irritation
- Causes severe skin burns.
- Serious eye damage/irritation
- Causes serious eye damage.
- Respiratory or skin sensitisation
- Not a skin sensitizer.
- Germ cell mutagenicity
- Not classified
- Carcinogenicity
- Not classified
- Specific target organ toxicity (single exposure)
- May cause respiratory irritation.
- Specific target organ toxicity (repeated exposure)
- Not classified
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- UN 2699
- UN-No. (IMDG)
- UN 2699
- UN-No. (IATA)
- UN 2699
- UN-No. (ADN)
- UN 2699
- UN-No. (RID)
- UN 2699
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Trifluoroacetic Acid
- Proper Shipping Name (IMDG)
- Trifluoroacetic Acid
- Proper Shipping Name (IATA)
- Trifluoroacetic Acid
- Proper Shipping Name (ADN)
- Trifluoroacetic Acid
- Proper Shipping Name (RID)
- Trifluoroacetic Acid
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 8
14.4 — Packing group
- Packing group (ADR)
- I
- Packing group (IMDG)
- I
- Packing group (IATA)
- I
- Packing group (ADN)
- I
- Packing group (RID)
- I
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Trifluoroacetic acid is primarily used as a standard cleavage reagent in solid-phase peptide synthesis, where it facilitates the removal of protecting groups from amino acids. Additionally, it serves as an ion-pairing acid additive in reversed-phase high-performance liquid chromatography (HPLC), enhancing the separation of analytes. Its applications extend to the pharmaceutical industry for drug development and analysis, as well as in the production of fluorinated compounds. Furthermore, TFA is utilized in various organic synthesis reactions, making it a versatile reagent in both academic and industrial laboratories.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL02580
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 114.02 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay | ≥ 98% | 99.5% |
| Density | 1.489 g/mL | 1.490 g/mL |
| Boiling Point | 72 °C | 72.5 °C |
| Melting Point | -15 °C | -14.5 °C |
| Moisture Content | ≤ 0.5% | 0.3% |
| Residue on Ignition | ≤ 0.1% | 0.05% |
| Related Substances | None detected | None detected |
The above product is expected to comply with 98% Extra Pure grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| 98% Extra Pure | ≥ 98% | -15 °C / 72 °C | ≤ 0.5% | ≤ 0.1% | None detected | Miscible in water |
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