Trifluoroacetic Anhydride
- CAS Number
- 407-25-0
- HSN Code
- 29159099
- Molecular Formula
- C4F6O3
- Catalogue Number
- AL2580B
- Purity
- ≥99%
- Molecular Weight
- 210.03 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Trifluoroacetic anhydride (TFAA) is a highly reactive acylating reagent primarily utilized in protein sequencing and organic synthesis. With a purity of 99%, it is specifically designed for sequential analysis applications. TFAA is notable for its ability to introduce trifluoroacetyl groups into various substrates, enhancing their stability and facilitating further chemical transformations. Its unique properties make it an essential tool in both academic and industrial laboratories focused on organic chemistry and biochemistry.
Also known as TFAA.
- Catalogue No.
- AL2580B
- CAS Number
- 407-25-0
- Molecular Formula
- C4F6O3
- Molecular Weight
- 210.03 g/mol
- HSN Code
- 29159099
- Grade
- 99%
- Product Form
- Substance
Trifluoroacetic anhydride is a colorless to pale yellow fuming liquid with a density of 1.511 g/mL at 20°C. It has a boiling point of approximately 56°C and a melting point of -20°C. The compound is highly soluble in organic solvents such as dichloromethane and acetonitrile, but it reacts vigorously with water, producing trifluoroacetic acid. TFAA has a strong, pungent odor characteristic of acylating agents, and it is classified as a corrosive substance due to its reactivity with moisture.
- Appearance
- Colorless to pale yellow fuming liquid
- Shelf Life
- Stable under recommended storage conditions
- Packaging
- Available in glass bottles or metal containers
- Storage
- Store in a cool, dry place away from moisture and incompatible materials.
1.1 — Product identifier
- Chemical Name
- Trifluoroacetic Anhydride
- Catalogue No.
- AL2580B
- Product form
- Substance
- CAS Number
- 407-25-0
- EC Number
- 206-991-8
- Grade
- 99%
- EC Index Number
- 607-195-00-7
- Chemical Formula
- C4F6O3
- HSN Code
- 29159099
- Synonyms
- TFAA
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Acylating reagent for protein sequencing and organic synthesis
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.3 — Other hazards
- Other hazards
- Corrosive to metals; may cause severe skin burns and eye damage.
3.1 — Substance
- Name
- Trifluoroacetic Anhydride
- CAS No.
- 407-25-0
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If breathing is difficult, give oxygen. Seek medical attention immediately.
- First-aid measures after skin contact
- Remove contaminated clothing and wash skin thoroughly with soap and water. Seek medical attention if irritation persists.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing and seek medical attention.
- First-aid measures after ingestion
- Do not induce vomiting. Rinse mouth and seek medical attention immediately.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Severe irritation, burns, and potential respiratory distress upon exposure.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- May produce toxic fumes in a fire; use appropriate fire-fighting measures.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Evacuate area and ventilate. Contain spill and absorb with inert material.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Neutralize with a suitable agent and dispose of in accordance with local regulations.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Use in a fume hood with appropriate personal protective equipment (PPE) including gloves and goggles.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Store in tightly closed containers in a cool, dry place away from moisture and incompatible materials.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respiratory protection when handling this substance in poorly ventilated areas.
9.1 — Information on basic physical and chemical properties
- Physical state
- Liquid
- Colour
- Colorless to pale yellow
- Odour
- Pungent
- Odour threshold
- Not specified
- pH value
- Not applicable
- Relative evaporation rate (butylacetate=1)
- Not specified
- Melting point
- -20°C
- Freezing point
- Not specified
- Boiling point
- 56°C
- Flash point
- Not applicable
- Auto-ignition temperature
- Not specified
- Decomposition temperature
- Not specified
- Flammability (solid, gas)
- Not flammable
- Vapour pressure
- Not specified
- Relative vapour density at 20°C
- Not specified
- Density
- 1.511 g/mL
- Solubility
- Reacts with water; soluble in organic solvents
- Log Pow
- Not specified
- Viscosity, kinematic
- Not specified
- Viscosity, dynamic
- Not specified
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- Not applicable
10.1 — Reactivity
- Reactivity
- Highly reactive with water and moisture; can cause violent reactions.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Water, strong bases, and strong oxidizing agents.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- Toxic if inhaled or absorbed through skin; may cause severe burns.
- Skin corrosion/irritation
- Causes severe skin burns and eye damage.
- Serious eye damage/irritation
- Causes serious eye damage.
- Respiratory or skin sensitisation
- Not classified as a sensitizer.
- Germ cell mutagenicity
- Not classified
- Carcinogenicity
- Not classified
- Specific target organ toxicity (single exposure)
- May cause respiratory irritation.
- Specific target organ toxicity (repeated exposure)
- Not classified
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- 3265
- UN-No. (IMDG)
- 3265
- UN-No. (IATA)
- 3265
- UN-No. (ADN)
- 3265
- UN-No. (RID)
- 3265
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Corrosive liquid, acidic, organic, n.o.s. (Trifluoroacetic anhydride)
- Proper Shipping Name (IMDG)
- Corrosive liquid, acidic, organic, n.o.s. (Trifluoroacetic anhydride)
- Proper Shipping Name (IATA)
- Corrosive liquid, acidic, organic, n.o.s. (Trifluoroacetic anhydride)
- Proper Shipping Name (ADN)
- Corrosive liquid, acidic, organic, n.o.s. (Trifluoroacetic anhydride)
- Proper Shipping Name (RID)
- Corrosive liquid, acidic, organic, n.o.s. (Trifluoroacetic anhydride)
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 8
14.4 — Packing group
- Packing group (ADR)
- I
- Packing group (IMDG)
- I
- Packing group (IATA)
- I
- Packing group (ADN)
- I
- Packing group (RID)
- I
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Trifluoroacetic anhydride is widely used in the field of biochemistry, particularly in Edman degradation for protein sequencing, where it acts as an acylating agent to facilitate the identification of amino acid sequences. Additionally, it is employed in the trifluoroacetylation of various organic compounds, which is crucial for improving the volatility and stability of analytes in gas chromatography. TFAA is also utilized in the synthesis of pharmaceuticals and agrochemicals, where its reactivity is harnessed to create complex molecular structures.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL2580B
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 210.03 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay | ≥99% | 99.5% |
| Density | 1.511 g/mL | 1.511 g/mL |
| Boiling Point | 56°C | 56°C |
| Moisture Content | ≤0.5% | 0.3% |
| Residue on Ignition | ≤0.1% | 0.05% |
| Related Substances | None detected | None detected |
The above product is expected to comply with 99% grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| 99% | ≥99% | -20°C to 56°C | ≤0.5% | ≤0.1% | None detected | Soluble in organic solvents, reacts with water |
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