Trimethyl Phosphite
- CAS Number
- 121-45-9
- HSN Code
- 29202300
- Molecular Formula
- C3H9O3P
- Catalogue Number
- AL2582E
- Purity
- ≥ 98%
- Molecular Weight
- 124.08 g/mol
Complies with : IP | BP | USP | EP | ACS
ISO 9001
ISO 14001
GMP
COA with every batch
Key Properties
Trimethyl phosphite (for synthesis) is a reactive phosphorus(III) ester that plays a crucial role in various chemical reactions, particularly in the synthesis of organophosphorus compounds. It is widely recognized for its application in the Arbuzov reaction, where it facilitates the formation of phosphonate esters. This compound is notable for its high purity of 98%, making it suitable for sensitive synthetic applications. With a CAS number of 121-45-9, trimethyl phosphite is an essential reagent in organic chemistry, particularly in the development of agrochemicals and pharmaceuticals.
Also known as Trimethyl phosphite, Phosphorous acid trimethyl ester.
- Catalogue No.
- AL2582E
- CAS Number
- 121-45-9
- Molecular Formula
- C3H9O3P
- Molecular Weight
- 124.08 g/mol
- HSN Code
- 29202300
- Grade
- 98%
- Product Form
- Substance
Trimethyl phosphite is a colorless liquid with a density of 1.052 g/mL at 20°C. It has a boiling point of approximately 165°C and a flash point of 40°C, indicating its flammable nature. The compound is soluble in organic solvents such as ethanol and ether, but it is not miscible with water. Its refractive index is around 1.426, and it has a viscosity of 1.2 mPa·s at 20°C. The compound has a mild, characteristic odor, which is typical of phosphorus esters.
- Appearance
- Colorless liquid
- Shelf Life
- 2 years
- Packaging
- Available in 1L and 5L glass bottles
- Storage
- Store in a cool, dry place away from heat and ignition sources.
1.1 — Product identifier
- Chemical Name
- Trimethyl Phosphite
- Catalogue No.
- AL2582E
- Product form
- Substance
- CAS Number
- 121-45-9
- EC Number
- 204-112-2
- Grade
- 98%
- EC Index Number
- phosphonic acid esters
- Chemical Formula
- C3H9O3P
- HSN Code
- 29202300
- Synonyms
- Trimethyl phosphite, Phosphorous acid trimethyl ester
1.2 — Relevant identified uses of the substance or mixture and uses advised against
- Use of the substance/mixture
- Used as a reagent in organic synthesis, particularly in the production of phosphonate esters.
- Uses advised against
- Not specified
1.3 — Details of the supplier of the safety data sheet
- Company identification
- Address:- 102, B wing, Savgan Heights, RTO Lane,Andheri (W), Mumbai-400 053Maharashtra, India.
1.4 — Emergency Contact Details
- Phone / e-Mail
- Phone : +91 22 26317055 Mobile : +91 9820385757 e-mail : info@alphachemika.co.in
2.3 — Other hazards
- Other hazards
- May cause respiratory irritation; vapors may be harmful.
3.1 — Substance
- Name
- Trimethyl Phosphite
- CAS No.
- 121-45-9
4.1 — Description of first aid measures
- First-aid measures after inhalation
- Move to fresh air. If symptoms persist, seek medical attention.
- First-aid measures after skin contact
- Wash with soap and water. If irritation occurs, seek medical attention.
- First-aid measures after eye contact
- Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. If irritation persists, seek medical attention.
- First-aid measures after ingestion
- Do not induce vomiting. Rinse mouth and seek medical attention immediately.
4.2 — Most important symptoms and effects, both acute and delayed
- Symptoms relating to use
- Irritation of the eyes, skin, and respiratory tract; headache; dizziness.
4.3 — Indication of any immediate medical attention and special treatment needed
- General information
- Treat symptomatically. Show this safety data sheet to the treating physician.
5.1 — Extinguishing media
- Suitable extinguishing media
- Water spray, carbon dioxide, dry chemical powder, foam.
- Unsuitable extinguishing media
- Not specified
5.2 — Special hazards arising from the substance or mixture
- Special procedures
- Flammable liquid; may produce toxic fumes in a fire.
5.3 — Advice for firefighters
- Protection during firefighting
- Do not enter fire area without proper protective equipment, including respiratory protection.
6.1.1 — For non-emergency personnel
- Emergency procedures
- Evacuate area and ventilate. Use appropriate protective equipment.
6.3 — Methods and material for containment and cleaning up
- Methods for cleaning up
- Contain spill and absorb with inert material. Dispose of in accordance with local regulations.
6.4 — Reference to other sections
- Reference
- Not specified
7.1 — Precautions for safe handling
- Precautions for safe handling
- Avoid contact with skin and eyes. Use in a well-ventilated area and avoid inhalation of vapors.
- Hygiene measures
- Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work.
7.2 — Conditions for safe storage, including any incompatibilities
- Storage conditions
- Store in tightly closed containers in a cool, dry place away from heat sources.
8.2 — Exposure controls
- Hand protection
- Protective gloves (e.g. nitrile rubber)
- Eye protection
- Chemical safety goggles or safety glasses
- Skin and body protection
- Wear suitable protective clothing
- Respiratory protection
- Use appropriate respiratory protection if ventilation is inadequate.
9.1 — Information on basic physical and chemical properties
- Physical state
- Liquid
- Colour
- Colorless
- Odour
- Mild, characteristic
- Odour threshold
- No data available
- pH value
- No data available
- Relative evaporation rate (butylacetate=1)
- No data available
- Melting point
- -50°C
- Freezing point
- No data available
- Boiling point
- 165°C
- Flash point
- 40°C
- Auto-ignition temperature
- No data available
- Decomposition temperature
- No data available
- Flammability (solid, gas)
- Flammable liquid
- Vapour pressure
- 0.5 mmHg at 20°C
- Relative vapour density at 20°C
- No data available
- Density
- 1.052 g/mL
- Solubility
- Soluble in organic solvents, insoluble in water
- Log Pow
- No data available
- Viscosity, kinematic
- No data available
- Viscosity, dynamic
- 1.2 mPa·s at 20°C
- Explosive properties
- Not explosive
- Oxidising properties
- Not oxidizing
- Explosive limits
- No data available
10.1 — Reactivity
- Reactivity
- Reacts with strong oxidizing agents and bases.
10.2 — Chemical stability
- Chemical stability
- Stable under recommended storage conditions.
10.3 — Possibility of hazardous reactions
- Possibility of hazardous reactions
- No dangerous reactions known under normal conditions of use.
10.4 — Conditions to avoid
- Conditions to avoid
- Avoid contact with incompatible materials and excessive heat.
10.5 — Incompatible materials
- Incompatible materials
- Strong oxidizers, strong bases.
10.6 — Hazardous decomposition products
- Hazardous decomposition products
- Not specified
11.1 — Information on toxicological effects
- Acute toxicity
- LD50 (oral, rat) > 2000 mg/kg.
- Skin corrosion/irritation
- May cause skin irritation.
- Serious eye damage/irritation
- Causes serious eye irritation.
- Respiratory or skin sensitisation
- Not a skin sensitizer.
- Germ cell mutagenicity
- Not classified
- Carcinogenicity
- Not classified
- Specific target organ toxicity (single exposure)
- May cause respiratory irritation.
- Specific target organ toxicity (repeated exposure)
- Not classified
12.1 — Toxicity
- Toxicity information
- Not specified
12.2 — Persistence - degradability
- Persistence - degradability
- Not specified
12.3 — Bioaccumulative potential
- Bioaccumulative potential
- Not specified
12.4 — Mobility in soil
- Mobility in soil
- Not specified
12.6 — Other adverse effects
- Environmental precautions
- Not specified
13.1 — Waste treatment methods
- Additional Info
- Dispose of contents/container in accordance with local, regional, national and international regulations.
14.1 — UN number
- UN-No. (ADR)
- UN 2329
- UN-No. (IMDG)
- UN 2329
- UN-No. (IATA)
- UN 2329
- UN-No. (ADN)
- UN 2329
- UN-No. (RID)
- UN 2329
14.2 — UN proper shipping name
- Proper Shipping Name (ADR)
- Trimethyl phosphite
- Proper Shipping Name (IMDG)
- Trimethyl phosphite
- Proper Shipping Name (IATA)
- Trimethyl phosphite
- Proper Shipping Name (ADN)
- Trimethyl phosphite
- Proper Shipping Name (RID)
- Trimethyl phosphite
14.3 — Transport hazard class(es)
- Transport hazard class(es)
- 3
14.4 — Packing group
- Packing group (ADR)
- III
- Packing group (IMDG)
- III
- Packing group (IATA)
- III
- Packing group (ADN)
- III
- Packing group (RID)
- III
14.5 — Environmental hazards
- Dangerous for the environment
- Not specified
- Marine pollutant
- Not specified
- Other information
- No supplementary information available
15.1 — Safety, health and environmental regulations/legislation specific for the substance or mixture
- 15.1.1 EU-Regulations
- Not specified
Trimethyl phosphite is primarily used as a reagent in the Michaelis-Arbuzov reaction, which is essential for synthesizing phosphonate esters in organophosphorus chemistry. This compound is also utilized in the production of flame retardants, plasticizers, and agricultural chemicals. In the pharmaceutical industry, it serves as an intermediate in the synthesis of various bioactive compounds. Additionally, trimethyl phosphite is employed in the preparation of organophosphorus ligands for catalysis and in the development of new materials with specific chemical properties.
ISO 9001
ISO 14001
GMP
COA with every batch
- Batch Number
- AL-2026-AL2582E
- Manufacturing Date
- September-2026
- Expiry Date
- September-2031
- Molecular Weight
- 124.08 g/mol
| Test | Standard | Observed |
|---|---|---|
| Assay | ≥ 98% | 98.5% |
| Density | 1.052 g/mL | 1.052 g/mL |
| Boiling Point | 165°C | 165°C |
| Flash Point | 40°C | 40°C |
| Moisture Content | ≤ 0.5% | 0.3% |
| Residue on Ignition | ≤ 0.1% | 0.05% |
| Related Substances | None detected | None detected |
The above product is expected to comply with 98% grade specification.
Technical Data Sheet
| Grade | Assay/Purity | Melting/Boiling Point | Moisture/LOD | Residue on Ignition | Related Substances | Solubility |
|---|---|---|---|---|---|---|
| 98% | ≥ 98% | 165°C | ≤ 0.5% | ≤ 0.1% | None detected | Soluble in organic solvents |
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